Table 50Summary of included studies. Comparison 49. Augmenting with antipsychotic versus switch to bupropion

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Mohamed 2017

RCT

US

N=1016

Mean age (years): 54.4

Gender (% female): 14

Ethnicity (% BME): 32

Baseline severity: QIDS 16.75 (more severe)

Aripiprazole 2-15mg/day + SSRI/SNRIBupropion monotherapy 150-400mg/dayInadequate response (QIDS score ≥16 after ≥6 weeks of treatment or score≥11 after ≥8 weeks of treatment with the 3 most recent weeks at a stable “optimal” dose) to a treatment course with a SSRI, SNRI, or mirtazapine that met or exceeded minimal standards for dose and duration of treatment

Treatment length (weeks): 12

Outcomes:

  • Remission
  • Response
  • Discontinuation due to any reason
  • Discontinuation due to side effects

BME: black and minority ethnic; QIDS: quick inventory of depressive symptomatology; RCT: randomised controlled trial; SNRI: serotonin-norepinephrine reuptake inhibitor; SSRI: selective serotonin reuptake inhibitor

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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