Table 52Summary of included studies. Comparison 51. Augmenting with buspirone versus bupropion

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Trivedi 2006

RCT

US

N=565

Mean age (years): 41.1

Gender (% female): 59

Ethnicity (% BME): 22

Baseline severity: HAMD 15.8 (less severe)

Buspirone 15-60mg/day (mean final dose 40.9 mg/day) + citalopramBupropion sustained release 200-400mg/day (mean final dose 267.5 mg/day) + citalopramInadequate response (without remission [HAMD>7]) to a mean of 11.9 weeks of citalopram therapy (mean final dose 55mg/day)

Treatment length (weeks): 6

Outcomes:

  • Depression symptomatology endpoint
  • Depression symptomatology change score
  • Remission
  • Response
  • Discontinuation due to side effects

BME: black and minority ethnic; HAMD: Hamilton depression scale; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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