Table 6Summary of included studies. Comparison 5. Augmenting with short-term psychodynamic psychotherapy versus continuing with antidepressant

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Town 2017/2020

RCT

Canada

N=60

Mean age (years): 41.6

Gender (% female): 63

Ethnicity (% BME): 3

Baseline severity: HAMD 23.77 (more severe)

Intensive short-term dynamic psychotherapy + any antidepressant

Intensity: 20 sessions

Any antidepressantInadequate response to treatment (HAMD score ≥16) to at least 1 trial of antidepressants at the adequate recommended therapeutic dose. 34% 2 or more failed antidepressants for current episode

Treatment length (weeks): 26

Outcomes:

  • Depression symptomatology at:
    • Endpoint
    • 3-month follow-up
    • 6-month follow-up
    • 12-month follow-up
  • Depression symptomatology change score
  • Remission at:
    • Endpoint
    • 12-month follow-up
  • Response
  • Discontinuation due to any reason

BME: black and minority ethnic; HAMD: Hamilton depression scale; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.