Table 62, Summary of included studies. Comparison 61. Augmenting with ECT versus continuing with antidepressant - Further-line treatment

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Study	Population	Intervention	Comparison	Details of inadequate response/treatment resistance	Comments
Haghighi 2013 RCT Iran	N=40 Mean age (years): 31.5 Gender (% female): 30 Ethnicity (% BME): NR Baseline severity: HAMD 37.2 (more severe)	12 ECT sessions + citalopram 40mg/day	Citalopram 40mg/day	Inadequate response to 2-weeks of citalopram (40mg/day) and ECT recommended by 2 independent psychiatrists	Treatment length (weeks): 4 Outcomes: Depression symptomatology endpoint Depression symptomatology change score

Study

Population

Intervention

Comparison

Details of inadequate response/treatment resistance

Comments

RCT

Iran

N=40

Mean age (years): 31.5

Gender (% female): 30

Ethnicity (% BME): NR

Baseline severity: HAMD 37.2 (more severe)

12 ECT sessions + citalopram 40mg/day

Citalopram 40mg/day

Inadequate response to 2-weeks of citalopram (40mg/day) and ECT recommended by 2 independent psychiatrists

Treatment length (weeks): 4

Outcomes:

: BME: black and minority ethnic; ECT: electroconvulsive therapy; HAMD: Hamilton depression scale; NR: not reported; RCT: randomised controlled trial

Further-line treatment: Depression in adults: Evidence review D.

NICE Guideline, No. 222.

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