Table 65Summary of included studies. Comparison 64. Augmenting with exercise versus TAU

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Danielsson 2014

RCT

Sweden

N=42

Mean age (years): 45.5

Gender (% female): 76

Ethnicity (% BME): NR

Baseline severity: MADRS 24 (more severe)

Aerobic exercise + SSRI/SNRI

Intensity: 2 individual sessions + 16x twice-weekly 1-hour group training sessions

Enhanced TAU + SSRI/SNRI

Intensity: 1 session

Inadequate response (retained diagnosis) to a course of antidepressants, of at least 6 weeks duration

Treatment length (weeks): 10

Outcomes:

  • Depression symptomatology change score
  • Remission
  • Response
  • Discontinuation due to any reason

Ho 2014

RCT

China

N=52

Mean age (years): 46.2

Gender (% female): 67

Ethnicity (% BME): NR

Baseline severity: MADRS 19 (less severe)

Aerobic exercise group + any antidepressant

Intensity: 15x thrice-weekly 40-min sessions

Any antidepressantInadequate response: met inclusion criteria despite being on antidepressant at baseline

Treatment length (weeks): 3

Outcomes:

  • Depression symptomatology endpoint
  • Depression symptomatology change score
  • Remission

BME: black and minority ethnic; MADRS: Montgomery-Asberg depression rating scale; NR: not reported; RCT: randomised controlled trial; SNRI: serotonin-norepinephrine reuptake inhibitor; SSRI: selective serotonin reuptake inhibitor; TAU: treatment as usual

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.