| Study | Population | Intervention | Comparison | Details of inadequate response/treatment resistance | Comments |
|---|---|---|---|---|---|
|
RCT US |
N=73 Mean age (years): 70.6 Gender (% female): 62 Ethnicity (% BME): NR Baseline severity: HAMD 9 (less severe) |
Tai Chi + escitalopram 10-20mg/day Intensity: 10x 2-hour sessions |
Attention-placebo (health education) + escitalopram 10-20mg/day Intensity: 10x 2-hour sessions | Inadequate response to 4 weeks prospective treatment with escitalopram |
Treatment length (weeks): 10 Outcomes:
|
|
RCT UK |
N=86 Mean age (years): 65.0 Gender (% female): 69 Ethnicity (% BME): NR Baseline severity: HAMD 17.05 (more severe) |
Weight training class + any antidepressant Intensity: 20x twice-weekly 45-min sessions |
Attention-placebo (health education talks) + any antidepressant Intensity: 20x twice-weekly 30-40 min sessions | Inadequate response: all participants had been in receipt of a therapeutic dose of antidepressant therapy for at least 6 weeks without evidence of a sustained response prior to study entry |
Treatment length (weeks): 10 Outcomes:
|
|
RCT Portugal |
N=33 Mean age (years): 47.5 Gender (% female): 66 Ethnicity (% BME): NR Baseline severity: HAMD 17 (more severe) |
Aerobic exercise + any antidepressant Intensity: 60 sessions/12x 30-45min sessions supervised |
Attention-placebo (social interaction with study staff and peers) + any antidepressant Intensity: 12x 30-45min sessions | Inadequate response (failure to show clinical remission, HAMD>7) to combined therapy in doses considered adequate for 9-15 months |
Treatment length (weeks): 12 Outcomes:
|
BME: black and minority ethnic; HAMD: Hamilton depression scale; NR: not reported; RCT: randomised controlled trial
From: Further-line treatment
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