Table 67Summary of included studies. Comparison 66. Augmenting with exercise + ECT versus augmenting with ECT

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Salehi 2016

RCT

Iran

N=40

Mean age (years): 30.0

Gender (% female): 35

Ethnicity (% BME): NR

Baseline severity: HAMD 43.38 (more severe)

Exercise + ECT + citalopram 40mg/day

Intensity: Exercise: 12x thrice-weekly sessions; ECT: 12x thrice-weekly sessions

ECT + citalopram 40mg/day

Intensity: 12x thrice-weekly exercise sessions

Inadequate response to 2-weeks of citalopram (40mg/day) and ECT recommended by 2 independent psychiatrists

Treatment length (weeks): 4

Outcomes:

  • Depression symptomatology endpoint
  • Depression symptomatology change score
  • Remission

BME: black and minority ethnic; ECT: electroconvulsive therapy; HAMD: Hamilton depression scale; NR: not reported; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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