Table 68Summary of included studies. Comparison 67. Augmenting with yoga versus continuing with antidepressant (+/− waitlist or attention-placebo)

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Sharma 2017

RCT

US

N=25

Mean age (years): 37.2

Gender (% female): 72

Ethnicity (% BME): 8

Baseline severity: HAMD 20.4 (more severe)

Sudarshan Kriya yoga (SKY) group + any antidepressant

Intensity: 12 sessions

Waitlist + any antidepressantInadequate response: met inclusion criteria despite having received a stable dose of antidepressant treatment for at least 8 weeks

Treatment length (weeks): 8

Outcomes:

  • Depression symptomatology change score
  • Remission
  • Response
  • Discontinuation due to any reason

Uebelacker 2017

RCT

US

N=122

Mean age (years): 46.5

Gender (% female): 84

Ethnicity (% BME): 16

Baseline severity: QIDS 12.87 (more severe)

Hatha yoga group + any antidepressant

Intensity: 10-20x 80-min sessions

Attention-placebo (health living workshop) + any antidepressant

Intensity: 10-20x 60-min sessions

Inadequate response: met inclusion criteria despite currently taking an antidepressant at a dose with demonstrated effectiveness per American Psychiatric Association practice guidelines for at least 8 weeks

Treatment length (weeks): 10

Outcomes:

  • Remission at:
    • Endpoint
    • 3-month follow-up
    • 6-month follow-up
  • Response at:
    • Endpoint
    • 3-month follow-up
    • 6-month follow-up
  • Discontinuation due to any reason

BME: black and minority ethnic; HAMD: Hamilton depression scale; QIDS: quick inventory of depressive symptomatology; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.