Table 7, Summary of included studies. Comparison 6. Augmenting with long-term psychodynamic psychotherapy versus continuing with antidepressant - Further-line treatment

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Study	Population	Intervention	Comparison	Details of inadequate response/treatment resistance	Comments
Fonagy 2015 RCT UK	N=129 Mean age (years): 44.3 Gender (% female): 66 Ethnicity (% BME): NR Baseline severity: HAMD 20.1 (more severe)	Long-term psychodynamic psychotherapy (following manual by Taylor 2015) + any antidepressant Intensity: 60x 50-min weekly sessions	Any antidepressant	TRD: Inadequate response to least 2 different treatments (mean of 3.7 previously failed treatment attempts)	Treatment length (weeks): 78 Outcomes: Depression symptomatology at: Endpoint 6-month follow-up 12-month follow-up 24-month follow-up Remission at: Endpoint 24-month follow-up Discontinuation due to any reason

Study

Population

Intervention

Comparison

Details of inadequate response/treatment resistance

Comments

RCT

N=129

Mean age (years): 44.3

Gender (% female): 66

Ethnicity (% BME): NR

Baseline severity: HAMD 20.1 (more severe)

Long-term psychodynamic psychotherapy (following manual by Taylor 2015) + any antidepressant

Intensity: 60x 50-min weekly sessions

Any antidepressant

TRD: Inadequate response to least 2 different treatments (mean of 3.7 previously failed treatment attempts)

Treatment length (weeks): 78

Outcomes:

Depression symptomatology at:
- Endpoint
- 6-month follow-up
- 12-month follow-up
- 24-month follow-up
Remission at:
- Endpoint
- 24-month follow-up
Discontinuation due to any reason

: BME: black and minority ethnic; HAMD: Hamilton depression scale; NR: not reported; RCT: randomised controlled trial; TRD: treatment-resistant depression

Further-line treatment: Depression in adults: Evidence review D.

NICE Guideline, No. 222.

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