| Study | Population | Intervention | Comparison | Details of inadequate response/treatment resistance | Comments |
|---|---|---|---|---|---|
|
RCT Belgium & Netherlands |
N=44 Mean age (years): 42.3 Gender (% female): 64 Ethnicity (% BME): NR Baseline severity: HAMD 23.19 (more severe) |
Attentional bias training + any antidepressant Intensity: 1x pre-training lab session, 10x training sessions at home, & 1 post-training lab session |
Attention-placebo + any antidepressant Intensity: 1x pre-training lab session, 10x training sessions at home, & 1 post-training lab session | Inadequate response: met inclusion criteria despite all participants having received therapy and/or medication at study entry |
Treatment length (weeks): 1.4 Outcomes:
|
|
RCT China |
N=40 Mean age (years): 38.7 Gender (% female): 45 Ethnicity (% BME): NR Baseline severity: HAMD 23.01 (more severe) |
Attentional bias training + any antidepressant Intensity: 10 sessions (daily over 10 days) |
Attention-placebo + any antidepressant Intensity: 10 sessions (daily over 10 days) | Inadequate response (HAMD score≥20) despite at least 6 weeks of adequate antidepressant treatment |
Treatment length (weeks): 1.4 Outcomes:
|
|
RCT Austria |
N=90 Mean age (years): 47.8 Gender (% female): 67 Ethnicity (% BME): NR Baseline severity: HAMD 12.6 (less severe) |
Cognitive bibliotherapy + any antidepressant Intensity: 1 monitoring session | Any antidepressant | Inadequate response (not achieving full remission, HAMD score 10-19) to at least 1 course of a recommended dose of an antidepressant medication for at least 4 weeks (the median treatment duration with antidepressant medication before screening was 6 months) |
Treatment length (weeks): 6 Outcomes:
|
BME: black and minority ethnic; HAMD: Hamilton depression scale; NR: not reported; RCT: randomised controlled trial
From: Further-line treatment
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