Table 9, Clinical evidence summary: Mitral regurgitant volume on cardiac MRI - Evidence review for CT and MRI indications for intervention

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Table 9Clinical evidence summary: Mitral regurgitant volume on cardiac MRI

Risk factor and outcome (population)	Number of studies	Effect (95% CI)	Risk of bias	Imprecision	Indirectness	GRADE Quality
Mitral regurgitant volume per 10 mL on cardiac MRI for predicting mortality during follow-up Median follow-up 5.0 years (asymptomatic moderate or severe chronic organic MR; mean age 63 years)	1 (n=258)	Adjusted HR: 1.10 (1.05–1.20)^a	Very serious^b	None	None	LOW
Mitral regurgitant volume per 10 mL on cardiac MRI for predicting indication for surgery during follow-up Median follow-up 5.0 years (asymptomatic moderate or severe chronic organic MR; mean age 63 years)	1 (n=258)	Adjusted HR: 1.23 (1.06–1.29)^a	Very serious^b	None	None	LOW
MR volume ≤55 ml vs. >55 ml on cardiac MRI for predicting indication for surgery during follow-up Mean follow-up 2.5 years (asymptomatic moderate or severe chronic organic MR; mean age 64.8 years)	1 (n=109)	Unadjusted HR: 0.20 (0.09 to 0.45)^c	Very serious^b	None	None	LOW

Risk factor and outcome

(population)

Number of studies

Effect (95% CI)

Risk of bias

Imprecision

Indirectness

GRADE Quality

Mitral regurgitant volume per 10 mL on cardiac MRI for predicting mortality during follow-up

Median follow-up 5.0 years

(asymptomatic moderate or severe chronic organic MR; mean age 63 years)

1 (n=258)

Adjusted HR: 1.10 (1.05–1.20)^a

Very serious^b

None

LOW

Mitral regurgitant volume per 10 mL on cardiac MRI for predicting indication for surgery during follow-up

Median follow-up 5.0 years

(asymptomatic moderate or severe chronic organic MR; mean age 63 years)

1 (n=258)

Adjusted HR: 1.23 (1.06–1.29)^a

Very serious^b

None

LOW

MR volume ≤55 ml vs. >55 ml on cardiac MRI for predicting indication for surgery during follow-up

Mean follow-up 2.5 years

(asymptomatic moderate or severe chronic organic MR; mean age 64.8 years)

1 (n=109)

Unadjusted HR: 0.20 (0.09 to 0.45)^c

Very serious^b

None

LOW

(a): Methods: Adjusted for age, sex, and LVESVI on MRI.
(b): Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias
(c): Methods: no multivariable analysis, unadjusted HR reported in the paper

From: Evidence review for CT and MRI indications for intervention

Cover of Evidence review for CT and MRI indications for intervention

Evidence review for CT and MRI indications for intervention: Heart valve disease presenting in adults: investigation and management: Evidence review F.

NICE Guideline, No. 208.

London: National Institute for Health and Care Excellence (NICE); 2021 Nov.

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