• Women diagnosed with a missed miscarriage by pelvic ultrasound scan in the first 14 weeks of pregnancy

Population excludes:

• Women with a diagnosis of incomplete miscarriage
• Women opting for alternative methods of miscarriage management (expectant or surgical)
• Life threatening bleeding

• Mifepristone and misoprostol in combination

• Misoprostol and placebo

Critical

• Failure to spontaneously pass the gestational sac within 7 days after random assignment.
• Surgical intervention to complete the miscarriage up to discharge from hospital care.

Important

• Surgical intervention to complete the miscarriage up to and including 7 days after random assignment.
• Surgical intervention to complete the miscarriage from after day 7
• and up to discharge
• Need for further doses of misoprostol within 7 days after random assignment.
• Need for further doses of misoprostol up to discharge.
• Infection requiring outpatient antibiotic treatment.
• Infection requiring inpatient antibiotic treatment.
• Negative pregnancy test result 21 days (±2 days) after random assignment.
• Duration of bleeding as reported by the participant (days).
• Requirement for blood transfusion.
• Side-effects.
• Any serious complications.
• Maternal death

• RCT