Table 14Excluded studies and reasons for their exclusion

StudyReason for exclusion
(2013) Xofigo (radium-223 dichloride; Bayer HealthCare Pharmaceuticals Inc.) for treatment of bone metastases in castration-resistant prostate cancer. Lansdale, PA: HAYES, Inc Publication type does not match review protocol – conference abstract
(2011) Robotically assisted stereotactic radiosurgery (SRS) for spinal and extracranial head and neck indications. Lansdale, PA: HAYES, Inc Publication type does not match review protocol – conference abstract
Amouzegar-Hashemi, F, Behrouzi, H, Kazemian, A et al. (2008) Single versus multiple fractions of palliative radiotherapy for bone metastases: a randomized clinical trial in Iranian patients. Current oncology (toronto, ont.) 15(3): 36–39 [PubMed: 18317583] Population does not match review protocol
Bakar, D., Tanenbaum, J. E., Phan, K. et al. (2016) Decompression surgery for spinal metastases: a systematic review. Neurosurgical Focus 41: e2 Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Barrie, U., Elguindy, M., Pernik, M. et al. (2020) Intramedullary Spinal Metastatic Renal Cell Carcinoma: Systematic Review of Disease Presentation, Treatment, and Prognosis with Case Illustration. World Neurosurgery 134: 584–593 [PubMed: 31734421] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Bilsky, M. H.; Laufer, I.; Burch, S. (2009) Shifting paradigms in the treatment of metastatic spine disease. Spine 34: S101–7 [PubMed: 19829269] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Broder, M. S., Gutierrez, B., Cherepanov, D. et al. (2015) Burden of skeletal-related events in prostate cancer: unmet need in pain improvement. Supportive Care in Cancer 23(1): 237–247 [PubMed: 25270847] Population does not match review protocol
Cellini, F., Manfrida, S., Deodato, F. et al. (2019) Pain REduction with bone metastases STereotactic radiotherapy (PREST): A phase III randomized multicentric trial. Trials 20(1) Publication type does not match review protocol – study protocol
Chang, J. H., Shin, J. H., Yamada, Y. J. et al. (2016) Stereotactic Body Radiotherapy for Spinal Metastases: What are the Risks and How Do We Minimize Them?. Spine 41suppl20: S238–S245 [PubMed: 27488294] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Chen, B., Xiao, S., Tong, X. et al. (2015) Comparison of the Therapeutic Efficacy of Surgery with or without Adjuvant Radiotherapy versus Radiotherapy Alone for Metastatic Spinal Cord Compression: A Meta-Analysis. World Neurosurgery 83(6): 1066–1073 [PubMed: 25536156] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Chi, J. H., Gokaslan, Z., McCormick, P. et al. (2009) Selecting treatment for patients with malignant epidural spinal cord compressiondoes age matter? Results from a randomized clinical trial. Spine 34(5): 431–435 [PubMed: 19212272] Other protocol criteria - posthoc analysis of Patchell 2005 trial
Chow, E., Harris, K., Fan, G. et al. (2007) Palliative radiotherapy trials for bone metastases: a systematic review. Journal of Clinical Oncology 25: 1423–36 [PubMed: 17416863] Population does not match review protocol
Chow, E., Hoskin, P. J., Wu, J. et al. (2006) A phase III international randomised trial comparing single with multiple fractions for re-irradiation of painful bone metastases: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) SC 20. Clinical Oncology 18(2): 125–128 [PubMed: 16523812] Population does not match review protocol
Chow, E., van der Linden, Y. M., Roos, D. et al. (2014) Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial. Lancet Oncology 15: 164–71 [PubMed: 24369114] Population does not match review protocol
Chow, E., Zeng, L., Salvo, N. et al. (2012) Update on the systematic review of palliative radiotherapy trials for bone metastases. Clinical Oncology (Royal College of Radiologists) 24: 112–24 Population does not match review protocol
Dhamija, B.; Batheja, D.; Balain, B. S. (2021) A systematic review of MIS and open decompression surgery for spinal metastases in the last two decades. Journal of Clinical Orthopaedics & Trauma 22: 101596 [PubMed: 34631409] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Donovan, E. K., Sienna, J., Mitera, G. et al. (2019) Single versus multifraction radiotherapy for spinal cord compression: A systematic review and meta-analysis. Radiotherapy & Oncology 134: 55–66 [PubMed: 31005225] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Dy, S. M., Asch, S. M., Naeim, A. et al. (2008) Evidence-based standards for cancer pain management. Journal of Clinical Oncology 26(23): 3879–3885 [PubMed: 18688056] Population does not match review protocol
Falkmer, U., Jarhult, J., Wersall, P. et al. (2003) A systematic overview of radiation therapy effects in skeletal metastases. Acta Oncologica 42(5–6): 620–633 [PubMed: 14596519] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Feyer, P., Sautter-Bihl, M. L., Budachs, W. et al. (2010) DEGRO practical guidelines for palliative radiotherapy of breast cancer patients: Brain metastases and leptomeningeal carcinomatosis. Strahlentherapie und Onkologie 186(2): 63–69 [PubMed: 20127222] Population does not match review protocol
Garcia-Torralba, E., Spada, F., Lim, K. H. J. et al. (2021) Knowns and unknowns of bone metastases in patients with neuroendocrine neoplasms: A systematic review and meta-analysis. Cancer Treatment Reviews 94 (no pagination) Population does not match review protocol
George, R, Sundararaj, JJ, Govindaraj, R et al. (2015) Interventions for the treatment of metastatic extradural spinal cord compression in adults. Cochrane Database of Systematic Reviews Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Gerszten, P. C.; Mendel, E.; Yamada, Y. (2009) Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?. Spine 34: S78–92 [PubMed: 19829280] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Ghia, A. J., Chang, E. L., Bishop, A. J. et al. (2016) Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials. Journal of Neurosurgery Spine 24: 829–36 [PubMed: 26799117] Study design - phase I or II trials - patients not randomly allocated to treatment
Glicksman, R. M., Tjong, M. C., Neves-Junior, W. F. P. et al. (2020) Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases: A Review. JAMA Oncology 6: 567–577 [PubMed: 31895403] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Gong, Y., Xu, L., Zhuang, H. et al. (2019) Efficacy and safety of different fractions in stereotactic body radiotherapy for spinal metastases: A systematic review. Cancer Medicine 8: 6176–6184 [PubMed: 31489788] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Goodwin, C. R., Sankey, E. W., Liu, A. et al. (2016) A systematic review of clinical outcomes for patients diagnosed with skin cancer spinal metastases. Journal of Neurosurgery: Spine 24(5): 837–849 [PubMed: 26544595] Intervention does not match review protocol
Hamouda, W. E.; Roshdy, W.; Teema, M. (2007) Single versus conventional fractionated radiotherapy in the palliation of painful bone metastases. The gulf journal of oncology 1: 35–41 [PubMed: 20084712] Population does not match review protocol
Hernandez-Duran, S., Hanft, S., Komotar, R. J. et al. (2016) The role of stereotactic radiosurgery in the treatment of intramedullary spinal cord neoplasms: a systematic literature review. Neurosurgical Review 39(2): 175–183 [PubMed: 26219855] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Holt, T., Hoskin, P., Maranzano, E. et al. (2012) Malignant epidural spinal cord compression: the role of external beam radiotherapy. Current Opinion in Supportive & Palliative Care 6: 103–8 [PubMed: 22156794] Study design does not match review protocol – expert review/narrative
Howell, DD, James, JL, Hartsell, WF et al. (2009) Randomized trial of short-course versus long-course radiotherapy for palliation of painful vertebral bone metastases: a retrospective analysis of RTOG 97-14. Journal of clinical oncology 27(15sparti): 488 Publication type does not match review protocol – conference abstract
Husain, Z. A., Sahgal, A., De Salles, A. et al. (2017) Stereotactic body radiotherapy for de novo spinal metastases: systematic review. Journal of Neurosurgery Spine 27: 295–302 [PubMed: 28598293] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Jeremic, B. (2001) Single fraction external beam radiation therapy in the treatment of localized metastatic bone pain. A review. Journal of Pain and Symptom Management 22(6): 1048–1058 [PubMed: 11738168] Population does not match review protocol
Jeremic, B, Shibamoto, Y, Acimovic, L et al. (1998) A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. International journal of radiation oncology, biology, physics 42(1): 161–167 [PubMed: 9747834] Population does not match review protocol
Kim, J. M., Losina, E., Bono, C. M. et al. (2012) Clinical outcome of metastatic spinal cord compression treated with surgical excision +/- radiation versus radiation therapy alone: a systematic review of literature. Spine 37: 78–84 [PubMed: 21629164] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Klimo Jr, P., Thompson, C. J., Kestle, J. R. W. et al. (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro-Oncology 7(1): 64–76 [PubMed: 15701283] Intervention and comparator do not match review protocol
Kumar, N., Madhu, S., Bohra, H. et al. (2020) Is there an optimal timing between radiotherapy and surgery to reduce wound complications in metastatic spine disease? A systematic review. European Spine Journal 29: 3080–3115 [PubMed: 32556627] Outcomes do not match review protocol
Lee, C. H., Kwon, J. W., Lee, J. et al. (2014) Direct decompressive surgery followed by radiotherapy versus radiotherapy alone for metastatic epidural spinal cord compression: a meta-analysis. Spine 39: E587–92 [PubMed: 24503688] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Leer, JWH; Steenland, E; van Houwelingen, H (1999) Pain control for bone metastases. European journal of cancer 35(abstract462): 129 Publication type does not match review protocol – conference abstract
Loblaw, D. A. and Laperriere, N. J. (1998) Emergency treatment of malignant extradural spinal cord compression: An evidence-based guideline. Journal of Clinical Oncology 16(4): 1613–1624 [PubMed: 9552073] Publication type does not match review protocol – duplicate publication - updated version available
Loblaw, D. A., Mitera, G., Ford, M. et al. (2012) A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression. International Journal of Radiation Oncology, Biology, Physics 84: 312–7 [PubMed: 22420969] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Loblaw, D. A., Perry, J., Chambers, A. et al. (2005) Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative’s Neuro-Oncology Disease Site Group. Journal of Clinical Oncology 23: 2028–37 [PubMed: 15774794] Publication type does not match review protocol – duplicate publication - updated version available
Lohre, E. T.; Lund, J.; Kaasa, S. (2012) Radiation therapy in malignant spinal cord compression: what is the current knowledge on fractionation schedules? A systematic literature review. BMJ supportive & palliative care 2(1): 51–56 Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Lutz, S., Balboni, T., Jones, J. et al. (2017) Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline. Practical Radiation Oncology 7: 4–12 [PubMed: 27663933] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Ma, Y., He, S., Liu, T. et al. (2017) Quality of Life of Patients with Spinal Metastasis from Cancer of Unknown Primary Origin: A Longitudinal Study of Surgical Management Combined with Postoperative Radiation Therapy. Journal of Bone & Joint Surgery - American Volume 99: 1629–1639 [PubMed: 28976427] Study design does not match review protocol – non-randomised study
Maranzano, E., Trippa, F., Casale, M. et al. (2011) Reirradiation of metastatic spinal cord compression: definitive results of two randomized trials. Radiotherapy & Oncology 98: 234–7 [PubMed: 21295881] Study design does not match review protocol - post-hoc analysis (patients not randomised to re-treatment with radiotherapy)
Migliorini, F., Eschweiler, J., Trivellas, A. et al. (2021) Better pain control with 8-gray single fraction palliative radiotherapy for skeletal metastases: a Bayesian network meta-analysis. Clinical and Experimental Metastasis 38(2): 197–208 [PubMed: 33559808] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Moller, T. (1996) Skeletal metastases. Acta oncologica (Stockholm, Sweden) 35suppl7: 125–136 [PubMed: 9154105] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Moulding, H. D. and Bilsky, M. H. (2010) Metastases to the craniovertebral junction. Neurosurgery 66(SUPPL. 3): A113–A118 Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Myrehaug, S., Sahgal, A., Hayashi, M. et al. (2017) Reirradiation spine stereotactic body radiation therapy for spinal metastases: systematic review. Journal of Neurosurgery Spine 27: 428–435 [PubMed: 28708043] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Niewald, M., Tkocz, H. J., Abel, U. et al. (1996) Rapid course radiation therapy vs. more standard treatment: a randomized trial for bone metastases. International Journal of Radiation Oncology, Biology, Physics 36: 1085–9 [PubMed: 8985030] Population does not match review protocol - data for spinal metastases group not reported
Ozsaran, Z, Yalman, D, Anacak, Y et al. (2001) Palliative radiotherapy in bone metastases: results of a randomized trial comparing three fractionation schedules. Journal of B.U.ON. 6(1): 43–48 Population does not match review protocol
Pontoriero, A., Lillo, S., Caravatta, L. et al. (2021) Cumulative dose, toxicity, and outcomes of spinal metastases re-irradiation: Systematic review on behalf of the Re-Irradiation Working Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Strahlentherapie und Onkologie 197: 369–384 [PubMed: 33635395] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Qu, S., Meng, H. L., Liang, Z. G. et al. (2015) Comparison of shortcourse radiotherapy versus long-course radiotherapy for treatment of metastatic spinal cord compression: A systematic review and meta-analysis. Medicine (United States) 94(43) Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Quraishi, N. A., Giannoulis, K. E., Edwards, K. L. et al. (2012) Management of metastatic sacral tumours. European Spine Journal 21: 1984–93 [PubMed: 22729363] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Rades, D. (2010) Dose-fractionation schedules for radiotherapy of bone metastases. Breast Care 5(5): 339–344 [PubMed: 21779218] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Rades, D., Cacicedo, J., Conde-Moreno, A. J. et al. (2021) Comparison of 5 x 5 Gy and 10 x 3 Gy for metastatic spinal cord compression using data from three prospective trials. Radiation Oncology 16: 7 [PubMed: 33413492] Patients were not randomly allocated to treatment groups
Rich, S. E., Chow, R., Raman, S. et al. (2018) Update of the systematic review of palliative radiation therapy fractionation for bone metastases. Radiotherapy & Oncology 126: 547–557 [PubMed: 29397209] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Roos, D. E., O’Brien, P. C., Smith, J. G. et al. (2000) A role for radiotherapy in neuropathic bone pain: preliminary response rates from a prospective trial (Trans-tasman radiation oncology group, TROG 96.05). International Journal of Radiation Oncology, Biology, Physics 46: 975–81 [PubMed: 10705020] Other protocol criteria - data from preliminary analysis reported in Roos 2005 which has been included in this review
Roos, D. E., Davis, S. R., Turner, S. L. et al. (2003) Quality assurance experience with the randomized neuropathic bone pain trial (Trans-Tasman Radiation Oncology Group, 96.05). Radiotherapy & Oncology 67: 207–12 [PubMed: 12812852] Population does not match review protocol - data for spinal metastases group not reported
Roque i Figuls, M., Martinez-Zapata, M. J., Scott-Brown, M. et al. (2017) Radioisotopes for metastatic bone pain. Cochrane Database of Systematic Reviews 2017(3) Publication type does not match review protocol – duplicate publication - withdrawn version of a Cochrane review
Sahgal, A., Myrehaug, S. D., Siva, S. et al. (2020) CCTG SC.24/TROG 17.06: A Randomized Phase II/III Study Comparing 24Gy in 2 Stereotactic Body Radiotherapy (SABR) Fractions Versus 20Gy in 5 Conventional Palliative Radiotherapy (CRT) Fractions for Patients with Painful Spinal Metastases. International journal of radiation oncology, biology, physics 108(5): 1397–1398 Publication type does not match review protocol – conference abstract
Sande, T. A., Ruenes, R., Lund, J. A. et al. (2009) Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: results from a randomised multicentre trial. Radiotherapy & Oncology 91: 261–6 [PubMed: 19307034] Population does not match review protocol
Sapkaroski, D.; Osborne, C.; Knight, K. A. (2015) A review of stereotactic body radiotherapy - is volumetric modulated arc therapy the answer?. Journal of Medical Radiation Sciences 62(2): 142–151 [PubMed: 26229679] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Sharma, R., Sagoo, N. S., Haider, A. S. et al. (2021) Iodine-125 radioactive seed brachytherapy as a treatment for spine and bone metastases: A systematic review and meta-analysis. Surgical Oncology 38 (no pagination) Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Singh, R., Lehrer, E. J., Dahshan, B. et al. (2020) Single fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): A systematic review and meta-analysis. Radiotherapy & Oncology 146: 76–89 [PubMed: 32114269] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Smith, B. W., Joseph, J. R., Saadeh, Y. S. et al. (2018) Radiosurgery for Treatment of Renal Cell Metastases to Spine: A Systematic Review of the Literature. World Neurosurgery 109: e502–e509 [PubMed: 29038086] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Sohn, S. and Chung, C. K. (2012) The role of stereotactic radiosurgery in metastasis to the spine. Journal of Korean Neurosurgical Society 51: 1–7 [PubMed: 22396835] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Soltys, S. G., Grimm, J., Milano, M. T. et al. (2021) Stereotactic Body Radiation Therapy for Spinal Metastases: Tumor Control Probability Analyses and Recommended Reporting Standards. International Journal of Radiation Oncology, Biology, Physics 110: 112–123 [PubMed: 33516580] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Souchon, R., Wenz, F., Sedlmayer, F. et al. (2009) DEGRO practice guidelines for palliative radiotherapy of metastatic breast cancer: bone metastases and metastatic spinal cord compression (MSCC). Strahlentherapie und Onkologie 185: 417–24 [PubMed: 19714302] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Stebbing, J. and Ngan, S. (2010) Breast cancer (metastatic). BMJ clinical evidence Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Suppli, MH, Munck Af Rosenschold, P, Dahl, B et al. (2020) Premature Termination of a Randomized Controlled Trial on Image-Guided Stereotactic Body Radiotherapy of Metastatic Spinal Cord Compression. Oncologist 25(3): 210–e422 [PubMed: 32162821] Outcomes do not match review protocol – no outcomes reported (trial was closed prematurely)
Sze, W. M., Shelley, M., Held, I. et al. (2004) Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. Cochrane Database of Systematic Reviews: cd004721 Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Thirion, P. G., Dunne, M. T., Kelly, P. J. et al. (2020) Non-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression. British Journal of Cancer 122: 1315–1323 [PubMed: 32157242] Other protocol criteria - secondary publication of ICORG 05-03 trial (Lee 2018), but no additional relevant outcome data reported that match the protocol for this review
Trilling, G. M., Cho, H., Ugas, M. A. et al. (2012) Spinal metastasis in head and neck cancer. Head and Neck Oncology 4(1) Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
van der Linden, YM, Dijkstra, SP, Vonk, EJ et al. (2005) Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 103(2): 320–328 [PubMed: 15593360] Intervention does not match review protocol
Van Der Linden, YM, Steenland, E, Post, WJ et al. (2002) Singledose irradiation of painful bone metastases is as effective as multiple fractions. Outcome of the Dutch Bone Metastasis Study. Nederlands tijdschrift voor geneeskunde 146(35): 1645–1650 Other protocol criteria – not available in English
Verbiest, A., De Meerleer, G., Albersen, M. et al. (2018) Non-surgical ablative treatment of distant extracranial metastases for renal cell carcinoma: A systematic review. Kidney Cancer 2(1): 57–67 Intervention does not match review protocol
Westhoff, P. G., de Graeff, A., Monninkhof, E. M. et al. (2018) Effectiveness and toxicity of conventional radiotherapy treatment for painful spinal metastases: a detailed course of side effects after opposing fields versus a single posterior field technique. Journal of Radiation Oncology 7: 17–26 [PubMed: 29576859] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Wild, A. T. and Yamada, Y. (2017) Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer. Visceral Medicine 33: 54–61 [PubMed: 28612018] Publication type does not match review protocol – expert review/narrative
Wowra, B, Zausinger, S, Muacevic, A et al. (2009) Radiosurgery for spinal malignant tumors. Deutsches Aerzteblatt International 106(7): 106–112 Study design does not match review protocol – expert review/narrative
Yang, J., Yan, J., Zeng, M. et al. (2020) Bone metastases of gastrointestinal stromal tumor: A review of published literature. Cancer Management and Research 12: 1411–1417 [PubMed: 32161493] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Yao, A., Sarkiss, C. A., Ladner, T. R. et al. (2017) Contemporary spinal oncology treatment paradigms and outcomes for metastatic tumors to the spine: A systematic review of breast, prostate, renal, and lung metastases. Journal of Clinical Neuroscience 41: 11–23 [PubMed: 28462790] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies
Young, RF; Post, EM; King, GA (1980) Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. Journal of neurosurgery 53(6): 741–748 [PubMed: 7441333] Publication date before cutoff in review protocol
Zuckerman, S. L., Lim, J., Yamada, Y. et al. (2018) Brachytherapy in Spinal Tumors: A Systematic Review. World Neurosurgery 118: e235–e244 [PubMed: 29966796] Study design does not match protocol criteria - systematic review without pooled results/quantitative data, checked for relevant studies

From: Evidence reviews for radiotherapy

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Evidence reviews for radiotherapy: Spinal metastases and metastatic spinal cord compression: Evidence review M.
NICE Guideline, No. 234.
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