Table 5a.

WARS2-Related Epilepsy: Recommended Surveillance

System/ConcernEvaluationSuggested Frequency of Outpatient Surveillance After Initial Assessment
Neurologic status incl possible seizures / subclinical status epilepticus
  • Eval of seizure status by pediatric neurologist; to incl EEG & video EEG monitoring
  • Without seizure correlates, routine EEG is not indicated.
  • Assess for new manifestations, e.g., seizures, changes in tone, movement disorders.
At each visit (or per treating clinician)
Musculoskeletal Physical medicine, OT/PT assessment of mobility, need for adaptive devises
Development Monitor developmental progress & educational needs.
Gastrointestinal
  • Assessment of feeding
  • Monitoring of stool frequency
  • Dietary assessment to maintain adequate nutrition & growth
Growth Assessment of nutritional status, height, weight, & body mass index
Respiratory Monitor for evidence of aspiration, respiratory insufficiency.
Family/Community Assess family need for social work support (e.g., palliative/respite care, home nursing, other local resources), care coordination, or follow-up genetic counseling if new questions arise (e.g., family planning).

OT = occupational therapy; PT = physical therapy

From: WARS2 Deficiency

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