Table 1Summary of the protocol (PICO table)

PopulationWomen in the third stage of labour who have given birth (spontaneous or assisted vaginal birth) to a single baby, who went into labour at term (37 to 42 weeks of pregnancy)
InterventionIntravenous administration of oxytocin in the third stage of labour
ComparisonIntramuscular administration of oxytocin in the third stage of labour
Outcome

Critical

  • Maternal admission to intensive therapy unit or high-dependency area
  • Primary postpartum haemorrhage (PPH) at time of birth and up to 24 hours (PPH > 500 mL)
  • Severe PPH at time of birth and up to 24 hours (PPH > 1000 mL)

Important

  • Need for manual removal of placenta
  • Need for additional uterotonics during the third stage or within the first 48 hours
  • Side effects (for example, change in blood pressure, headache, nausea/ vomiting, pain analgesia) during the third stage of labour or within the first 24 hours
  • Women’s experience of labour and birth

PPH: postpartum haemorrhage

From: Evidence reviews for route of administration of oxytocin in the third stage of labour

Cover of Evidence reviews for route of administration of oxytocin in the third stage of labour
Evidence reviews for route of administration of oxytocin in the third stage of labour: Intrapartum care: Evidence review L.
NICE Guideline, No. 235.
Copyright © NICE 2023.

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