Table 1Summary of the protocol (PICO table)

Population
  • Women in labour who are pregnant with a single baby, who go into labour at term (37 to 42 weeks of pregnancy) and who do not have any pre-existing medical conditions or antenatal conditions that predispose to a higher risk birth
  • Women in labour whose baby has not been identified before labour to be at high risk of adverse outcome
  • Singleton babies born at term (37 to 42 weeks of pregnancy) with no previously identified problems (for example congenital malformations, genetic anomalies, intrauterine growth restriction, placental problems)
  • Women having an assisted vaginal birth (forceps or vacuum/suction birth) without evidence of an active infection or other conditions requiring antibiotics
InterventionProphylactic antibiotics given immediately before or as soon as possible after an assisted vaginal birth (forceps or vacuum birth)
Comparison
  • Placebo
  • Standard care (no antibiotics)
Outcome

Critical:

  • Endometritis
  • Infection at perineal/vaginal or episiotomy site (up till 6 weeks)
  • Sepsis following perineum infection or endometritis

Important:

  • Maternal adverse reaction to antibiotics
  • Long-term neonatal outcomes (asthma, allergies)
  • Breastfeeding at 6 weeks
  • Perineal pain at 6 weeks
  • Antibiotic resistance

From: Evidence reviews for prophylactic antibiotics for birth with forceps or ventouse

Cover of Evidence reviews for prophylactic antibiotics for birth with forceps or ventouse
Evidence reviews for prophylactic antibiotics for birth with forceps or ventouse: Intrapartum care: Evidence review J.
NICE Guideline, No. 235.
Copyright © NICE 2023.

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