Table 3, Economic evidence profile of a systematic review of economic evaluations of prophylactic antibiotics for preventing postnatal infections in assisted vaginal birth - Evidence reviews for prophylactic antibiotics for birth with forceps or ventouse

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Study	Limitations	Applicability	Other comments	Incremental	Uncertainty
Knight 2019 Prophylactic antibiot ic after operati ve birth versus placebo	Potentially serious limitations¹^,²	Directly applicable	Cost analysis alongside a randomised controlled trial	−£52	80 per 1000 fewer suspect ed or confirm ed infectio ns at 6 weeks post birth³	Domin ance	99% confidence intervals were reported for point estimates of mean difference in costs Sensitivity analysis was undertaken with imputation for missing data

Study

Limitations

Applicability

Other comments

Incremental

Uncertainty

Costs

Effect

Cost effecti venss

Prophylactic antibiot ic after operati ve birth versus placebo

Potentially serious limitations¹^,²

Directly applicable

Cost analysis alongside a randomised controlled trial

−£52

80 per 1000 fewer suspect ed or confirm ed infectio ns at 6 weeks post birth³

Domin ance

99% confidence intervals were reported for point estimates of mean difference in costs

Sensitivity analysis was undertaken with imputation for missing data

1: Staffing and consumable costs were not included in the intervention costs.
2: There were statistically significant differences in the characteristics of the women who returned the postal questionnaire and those who did not.
3: Taken from the primary outcome of the study but not reported as part of the cost analysis

Evidence reviews for prophylactic antibiotics for birth with forceps or ventouse: Intrapartum care: Evidence review J.

NICE Guideline, No. 235.

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