| Intervention | NMA OR (95% CrI) | NMA LogOR (95% CrI) | Number of studies providing direct evidence |
|---|---|---|---|
| Misoprostol >800 mcg and ≤ 1000 mcg | 0.000 (0.000, 0.065) | −44.31 (−81.14, −2.735) | - |
| Misoprostol >600 mcg and ≤ 800 mcg | 0.199 (0.045, 0.713) | −1.613 (−3.112, −0.339) | - |
| Carbetocin | 0.425 (0.293, 0.577) | −0.857 (−1.228, −0.551) | - |
| Ergometrine | 0.434 (0.214, 0.837) | −0.8344 (−1.54, −0.179) | 1 |
| Ergometrine plus oxytocin | 0.449 (0.332, 0.600) | −0.800 (−1.104, −0.511) | 2 |
| Carboprost | 0.467 (0.198, 1.116) | −0.762 (−1.621, 0.1096) | 1 |
| Oxytocin >1 IU and ≤ 5 IU | 0.548 (0.391, 0.766) | −0.601 (−0.938, −0.266) | 5 |
| Oxytocin >5 IU and ≤ 10 IU | 0.555 (0.435, 0.711) | −0.589 (−0.832, −0.341) | 4 |
| Misoprostol plus oxytocin | 0.569 (0.383, 0.838) | −0.565 (−0.961, −0.177) | - |
| Misoprostol ≤ 600 mcg | 0.647 (0.502, 0.817) | −0.436 (−0.690, −0.203) | 8 |
| Oxytocin > 10 IU | 0.803 (0.545, 1.170) | −0.2196 (−0.607, 0.157) | - |
| Oxytocin ≤1 IU | 0.824 (0.134, 5.018) | −0.1938 (−2.008, 1.613) | - |
Results from the random effects NMA. OR<1 favours the intervention (lower risk of PPH≥1000ml in the intervention arm) with lower numbers indicating greater benefit, OR>1 favours placebo. Abbreviations: OR, odds ratio; CrI, credible interval.
From: Evidence reviews for uterotonics for the prevention of postpartum haemorrhage
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