| Intervention | NMA blood loss ratio (95% CrI) | Number of studies providing direct evidence |
|---|---|---|
| Carbetocin | 0.6817 (0.5584, 0.8251) | - |
| Carboprost | 0.7038 (0.5772, 0.847) | 2 |
| Misoprostol plus oxytocin | 0.7817 (0.6185, 0.9731) | - |
| Misoprostol >600 mcg and ≤ 800 mcg | 0.7976 (0.6443, 0.9777) | 1 |
| Ergometrine plus oxytocin | 0.7977 (0.6755, 0.9358) | 2 |
| Oxytocin >5 IU and ≤ 10 IU | 0.8189 (0.7078, 0.9424) | 2 |
| Oxytocin >1 IU and ≤ 5 IU | 0.8328 (0.693, 0.9924) | 4 |
| Misoprostol >800 mcg and ≤ 1000 mcg | 0.8366 (0.5815, 1.163) | - |
| Misoprostol ≤ 600 mcg | 0.8368 (0.7295, 0.9565) | 7 |
| Ergometrine | 0.8626 (0.7373, 1.004) | 2 |
| Oxytocin ≤1 IU | 0.8714 (0.4275, 1.519) | - |
| Oxytocin > 10 IU | 0.9367 (0.7093, 1.209) | - |
Results from the random effects NMA. Blood loss ratio <1 favours the intervention (lower amount of blood lost in the intervention arm) with lower numbers indicating greater benefit, blood loss ratio>1 favours placebo. Abbreviations: OR, odds ratio; CrI, credible interval.
From: Evidence reviews for uterotonics for the prevention of postpartum haemorrhage
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