| I. Inherited Liver-Based Disorders |
| • Disorders causing damage to hepatocytes or to the liver architecture: |
| α1-antitrypsin deficiency |
| Glycogen storage diseases, e.g., von Gierke's disease and Pompe's disease |
| Wilson's disease |
| Progressive familial intrahepatic cholestasis |
| Tyrosinemia |
| • Disorders that do not affect hepatocyte longevity or liver architecture: |
| Crigler-Najjar syndrome type I |
| Familial hypercholesterolemia and other lipid metabolic disorders |
| Mucopolysaccharidosis VII |
| Ornithine transcarbamylase deficiency |
| Maple syrup urine disease |
| Phenylketonuria |
| Hemophilia A and B |
| Oxalosis |
| II. Acquired Diseases |
| • Infectious diseases: |
| Hepatitis B and C (prophylaxis and treatment), and malaria (prophylaxis). |
| • Liver tumors: |
| Hepatomas, cholangiocarcinomas, metastatic tumors |
| Extrahepatic tumors (inhibition of neovascularization) |
| • Cirrhosis of the liver |
| • Allograft or xenograft rejection |
From: Hepatocyte Transplantation and Liver-Directed Gene Therapy
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