| Study | Dataset | Sample Size | Marker Density | Software Packages |
|---|---|---|---|---|
| OBJECT: Determinants of PD risk | ||||
| De Stefano et al (Neurology 2001) | sib-pairs (GenePD study) | 113 ASP (102 families) | 11 cM (339 markers) | GENEHUNTER |
| Scott et al (JAMA 2001) | families with ≥2 aff. relatives | 260 ARP (174 families) | 10 cM (344 markers) | VITESSE/HOMOG (par.) GENEHUNTER-PLUS |
| Pankratz et al (Am J Hum Genet 2002) | sib-pairs (Parkinson Study Group) | 170 ASP (160 families) | 8.6 cM (400 markers) | MAPMAKER-SIBS |
| Hicks et al (Ann Neurology 2002) | isolated population (Iceland) | 117 patients (51 families) | <5 cM (781 markers) | ALLEGRO |
| OBJECT: Determinants of PD onset age (AAO) | ||||
| Li et al (Am J Hum Genet 2002) | families with ≥2 aff. relatives | see Scott et al 2001 | see Scott et al 2001 | SOLAR |
| De Stefano et al (Am J Hum Genet 2002) | sib-pairs (Gene PD study) | see De Stefano et al, 2001 | see De Stefano et al 2001 | GENEHUNTER |
From: Chromosome 1 and Other Hotspots for Parkinson's Disease Genes
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