Table 4Telomerase inhibition by non-template directed PNA (compiled from Hamilton et al47)

inhibitortarget sequence and functionIC50pre assembly μMIC50post assembly μM
PNA 22nt 57 to 67 (pseudoknot)a 0.12
PNA 23nt 180 to 194 (P3 helix)a 0.0110
PNA 24nt 291 to 303 (hTERT binding)0.05>100

a based on secondary structure of hTR described by Chen et al19

From: PNA and Oligonucleotide Inhibitors of Human Telomerase

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