From: Tyrosyl-tRNA Synthetases
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Mutation | ΔΔGS | ΔΔGT |
---|---|---|
T17A | - | 0 |
N146A | ++++ | 0 |
K151Nb | 0 | ++++ |
E152Ac | - | - |
W196Ad | ++ | +++ |
R207Q | nag | +++ |
K208N | na | +++ |
F323Ae | ++ | ++++ |
R368Qf | na | ++++ |
R371Q | na | +++ |
R407Q | na | +++ |
R408Q | na | +++ |
R410N | na | +++ |
K411N | na | +++ |
b Mutations K151A and K151Q suggested that K151N induces a conformational change.26
c Mutations E152D and E152Q had similar effects to those of E152A.27
d Mutation W196Q had a mild effect and W196F had no effect.26
e Mutations F323L, -Y and -W showed that the hydrophobic character of Phe323 was essential.29
f Mutation S356A in TyrRS from Acidithiobacillus ferrooxidans (equivalent to S366A in Bst-TyrRS) induces a variation ΔΔGS = 1.2 kcal·mol-1 (ref. 134).
g na, not available.
From: Tyrosyl-tRNA Synthetases
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.