From: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 2. Major Histopathological Categories of Non-Hodgkin Lymphoma in Children and Adolescentsa
| WHO Classification | Immunophenotype | Clinical Presentation | Chromosome Abnormalities | Genes Affected | |
|---|---|---|---|---|---|
| Burkitt and Burkitt-like lymphoma/leukemia | Mature B cell | Intra-abdominal (sporadic), head and neck (non-jaw, sporadic), jaw (endemic), bone marrow, CNS | t(8;14)(q24;q32), t(2;8)(p11;q24), t(8;22)(q24;q11) | C-MYC, IGH, IGK, IGL | |
| Diffuse large B-cell lymphoma | Mature B cell | Nodal, abdominal, bone, primary CNS (when associated with immunodeficiency), mediastinal | No consistent cytogenetic abnormality identified | ||
| Primary mediastinal B-cell lymphoma | Mature B cell, often CD30+ | Mediastinal, but may also have other nodal or extranodal disease (i.e., abdominal, often kidney) | 9p and 2p gains | JAK2, C-rel, SOCS1 | |
| Lymphoblastic lymphoma, precursor T-cell leukemia, or precursor B-cell lymphoma | Pre-T cell | Mediastinal, bone marrow | MTS1/p16ink4a; deletion TAL1 t(1;14)(p34;q11), t(11;14)(p13;q11) | TAL1, TCRAO, RHOMB1, HOX11, NOTCH1 | |
| Pre-B cell | Skin, bone, head and neck | ||||
| Anaplastic large cell lymphoma, systemic | CD30+ (Ki-1+) | Variable, but systemic symptoms often prominent | t(2;5)(p23;q35); less common variant translocations involving ALK | ALK, NPM | |
| T cell/null cell | |||||
| Anaplastic large cell lymphoma, cutaneous | CD30+ (Ki-usually) | Skin only; single or multiple lesions | Lacks t(2;5) | ||
| T cell | |||||
+ = positive; CNS = central nervous system; WHO = World Health Organization.
aAdapted from Percy et al.[1]