[Table], Table 3. Treatment Options for Childhood Non-Hodgkin Lymphoma (NHL) - PDQ Cancer Information Summaries

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Table 3. Treatment Options for Childhood Non-Hodgkin Lymphoma (NHL)

Treatment Group			Treatment Options
Mature B-cell NHL:
	Burkitt lymphoma/leukemia	Newly diagnosed	Surgery (for stage I and II only)
		Newly diagnosed	Chemotherapy with or without rituximab
		Recurrent	Chemotherapy with or without rituximab
		Recurrent	Allogeneic or autologous SCT
	Diffuse large B-cell lymphoma	Newly diagnosed	Surgery (for stage I and II only)
		Newly diagnosed	Chemotherapy with or without rituximab
		Recurrent	Chemotherapy with or without rituximab
		Recurrent	Allogeneic or autologous SCT
	Primary mediastinal B-cell lymphoma		Chemotherapy and rituximab
Lymphoblastic lymphoma		Newly diagnosed	Chemotherapy
		Newly diagnosed	Cranial radiation therapy for overt CNS disease only
		Recurrent	Nelarabine or nelarabine-containing chemotherapy regimens
			Chemotherapy
			Bortezomib with chemotherapy
			Allogeneic SCT
Anaplastic large cell lymphoma		Newly diagnosed	Surgery followed by chemotherapy (for stage I)
		Newly diagnosed	Chemotherapy
		Recurrent	Chemotherapy, brentuximab, and/or ALK inhibitors (e.g., crizotinib or alectinib)
		Recurrent	Allogeneic or autologous SCT
Lymphoproliferative disease associated with immunodeficiency:
	Lymphoproliferative disease associated with primary immunodeficiency		Chemotherapy with or without rituximab
			Allogeneic SCT
	NHL associated with DNA repair defect syndromes		Chemotherapy
	HIV-associated NHL		Chemotherapy with or without rituximab
	PTLD		Surgery and reduction of immunosuppressive therapy, if possible
			Rituximab alone
			Standard or slightly modified chemotherapy with or without rituximab (for B-cell PTLD)
			Low-dose chemotherapy with or without rituximab (for EBV-positive B-cell PTLD)
Rare NHL:
	Pediatric-type follicular lymphoma		Surgery only
	Pediatric-type follicular lymphoma		Chemotherapy with or without rituximab
	Marginal zone lymphoma		Surgery only
			Radiation therapy
			Rituximab with or without chemotherapy
			Antibiotic therapy, for MALT lymphoma
	Primary CNS lymphoma		Chemotherapy
	Primary CNS lymphoma		Radiation therapy
	Peripheral T-cell lymphoma		Chemotherapy
			Radiation therapy
			Allogeneic or autologous SCT
	Cutaneous T-cell lymphoma		No standard treatments have been established

: CNS = central nervous system; EBV = Epstein-Barr virus; MALT = mucosa-associated lymphoid tissue; PTLD = posttransplant lymphoproliferative disease; SCT = stem cell transplantation.

From: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)

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