Table 3. Treatment Options for Childhood Non-Hodgkin Lymphoma (NHL)

Treatment GroupTreatment Options
Mature B-cell NHL:
Burkitt lymphomaNewly diagnosedSurgery (for stage I and II only)
Chemotherapy with or without rituximab
Recurrent or refractory Chemotherapy with or without rituximab
Allogeneic or autologous HSCT
CAR T-cell therapy
Diffuse large B-cell lymphomaNewly diagnosedSurgery (for stage I and II only)
Chemotherapy with or without rituximab
Recurrent or refractory Chemotherapy with or without rituximab
Allogeneic or autologous HSCT
CAR T-cell therapy
Primary mediastinal B-cell lymphoma Chemotherapy and rituximab
Lymphoblastic lymphomaNewly diagnosed Chemotherapy
Cranial radiation therapy for overt CNS disease only
Recurrent or refractory Nelarabine or nelarabine-containing chemotherapy regimens
Chemotherapy
Bortezomib with chemotherapy
Allogeneic HSCT
Anaplastic large cell lymphomaNewly diagnosedSurgery followed by chemotherapy (for stage I)
Chemotherapy
Recurrent or refractory Chemotherapy, brentuximab, and/or ALK inhibitors (e.g., crizotinib or alectinib)
Allogeneic or autologous HSCT
Lymphoproliferative disease associated with immunodeficiency:
Lymphoproliferative disease associated with primary immunodeficiency Chemotherapy with or without rituximab
Allogeneic HSCT
NHL associated with DNA repair defect syndromes Chemotherapy
HIV-associated NHL Chemotherapy with or without rituximab
PTLDSurgery and reduction of immunosuppressive therapy, if possible
Rituximab alone
Standard or slightly modified chemotherapy with or without rituximab
Low-dose chemotherapy with or without rituximab
Rare NHL:
Pediatric-type follicular lymphoma Surgery only
Chemotherapy with or without rituximab
Marginal zone lymphoma Surgery only
Radiation therapy
Rituximab with or without chemotherapy
Antibiotic therapy, for MALT lymphoma
Primary CNS lymphoma Chemotherapy and rituximab
Radiation therapy
Peripheral T-cell lymphoma Chemotherapy
Radiation therapy
Allogeneic or autologous HSCT
Cutaneous T-cell lymphoma No standard treatments have been established
Mycosis fungoides No standard treatments have been established

CAR = chimeric antigen receptor; CNS = central nervous system; EBV = Epstein-Barr virus; MALT = mucosa-associated lymphoid tissue; PTLD = posttransplant lymphoproliferative disease; HSCT = hematopoietic stem cell transplant.

From: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
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