From: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 5. Standard Treatment Options for Burkitt Lymphoma and Diffuse Large B-cell Lymphoma
| Trial | Stratum | Disease Manifestations | Treatment |
|---|---|---|---|
| COG-C5961 (FAB/LMB-96) [22,27] COG-ANHL01 [31,32]; [24][Level of evidence C1] COG-ANHL1131 (Inter-B-NHL Ritux 2010) [26] | A | Completely resected stage I and abdominal stage II | Two cycles of chemotherapy [27] |
| B | Multiple extra-abdominal sites | Prephase + four cycles of chemotherapy (reduced-intensity arm) [22,34] | |
| Nonresected stage I and II, III (normal LDH) | |||
| Stage III (elevated LDH), marrow <25% blasts, no stage IV CNS disease | Prephase + four cycles of chemotherapy (reduced-intensity arm) + six doses of rituximab [26] | ||
| C | Mature B-cell ALL (>25% blasts in marrow) and/or stage IV CNS disease | Prephase + six cycles of chemotherapy (full-intensity arm) and only two maintenance cycles + six doses of rituximab [26] | |
| GER-GPOH-NHL-BFM-95 [21] | R1 | Completely resected stage I and abdominal stage II | Two cycles of chemotherapy |
| R2 | Nonresected stage I/II and stage III with LDH <500 IU/L | Prephase + four cycles of chemotherapy (4-hour methotrexate infusion) | |
ALL = acute lymphoblastic leukemia; BFM = Berlin-Frankfurt-Münster; CNS = central nervous system; COG = Children's Oncology Group; FAB = French-American-British; LDH = lactate dehydrogenase; LMB = Lymphome Malins de Burkitt; NHL = non-Hodgkin lymphoma; POG = Pediatric Oncology Group.