Table 5. 5-Year Survival Outcomes Among Patients With Concordant in Remission, Discordant, and Concordant Not in Remission End-of-Induction Bone Marrow MRD Levelsa

OutcomeM1/MRD <5%P valuebM1/MRD ≥5%P valuecM2/MRD ≥5%
Event-free survival rates:
B-ALL, overall87.1% ± 0.4% (n = 7,682)<.0001 59.1% ± 6.5% (n = 66) .00939.1% ± 7.9% (n = 40)
B-ALL, SR90.8% ± 0.4% (n = 5,000) .25 85.9% ± 7.6% (n = 22) .4576.2% ± 15.2% (n = 9)
B-ALL, HR80% ± 0.9% (n = 2,682) <.0001 44.9% ± 8.3% (n = 44) .0529% ± 8.2% (n = 31)
T-ALL87.6% ± 1.5% (n = 1,303) .01 80.3% ± 7.3% (n = 97).13 62.7% ± 13.5% (n = 40)
Overall survival rates:
B-ALL, overall93.8% ± 0.3% (n = 7,682) <.000177.2% ± 5.6% (n = 66) .0159% ± 8.9% (n = 40)
B-ALL, SR96.6% ± 0.3% (n = 5,000) .2495.5% ± 4.6% (n = 22 ).7588.9% ± 12.1% (n = 9)
B-ALL, HR88.4% ± 0.7% (n = 2,682) <.000166.9% ± 8.3% (n = 44).0651.4% ± 10.4% (n = 31)
T-ALL91.9% ± 1.3% (n = 1,303) .00583.4% ± 6.8% (n = 97).34 76.7% ± 12.3% (n = 40)

HR = high risk; MRD = minimal residual disease; SR = standard risk.

aAdapted from Gupta et al.[158]

bP value is comparing M1/MRD <5% with M1/MRD ≥5%.

cP value is comparing M1/MRD ≥5% with M2/MRD ≥5%.

From: Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)

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PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
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