From: Childhood Liver Cancer Treatment (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 3. A Comparison of the Use of PRETEXT in Risk Stratification Schemes for Hepatoblastomaa,b
| COG (AHEP-0731) | SIOPEL (SIOPEL-3, -3HR, -4, -6) | GPOH | JPLT (JPLT-2 and -3) | |
|---|---|---|---|---|
| Very low risk | PRETEXT I or II; pure fetal histology; primary resection at diagnosis | |||
| Low risk/standard risk | PRETEXT I or II of any histology with primary resection at diagnosis | PRETEXT I, II, or III | PRETEXT I, II, or III | PRETEXT I, II, or III |
| Intermediate riskb | PRETEXT II, III, or IV unresectable at diagnosis; or V+c, P+, E+; SCU histology | PRETEXT IV or any PRETEXT with rupture; or N1, P2, P2a, V3, V3a; or multifocal | ||
| High riskb | Any PRETEXT with M+; AFP level <100 ng/mL | Any PRETEXT; V+, P+, E+, M+; SCU histology; AFP level <100 ng/mL; tumor rupture | Any PRETEXT with V+, E+, P+, M+ or multifocal | Any PRETEXT with M1 or N2; or AFP level <100 ng/mL |
AFP = alpha-fetoprotein; COG = Children's Oncology Group; GPOH = Gesellschaft für Pädiatrische Onkologie und Hämatologie (Society for Paediatric Oncology and Haematology); JPLT = Japanese Study Group for Pediatric Liver Tumor; PRETEXT = PRE-Treatment EXTent of disease; SCU = small cell undifferentiated; SIOPEL = International Childhood Liver Tumors Strategy Group.
aAdapted from Czauderna et al.[58]
bRefer to Table 1 for more information about the annotations used in PRETEXT.
cThe COG and PRETEXT definitions of vascular involvement differ.