| Stage | TNM | Description |
|---|---|---|
| III | T1, T2, T3, or T4; N1; M0 | T1, T2, T3, or T4 = See Stage IV Neuroendocrine Tumors of the Appendix below in Table 17. |
| N1 = Regional lymph node metastasis. | ||
| M0 = No distant metastasis. | ||
| T4, N0, M0 | T4 = Tumor perforates the peritoneum or directly invades other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. | |
| N0 = No regional lymph node metastasis. | ||
| M0 = No distant metastasis. |
T = primary tumor; N = regional lymph nodes; M = distant metastasis.
aReprinted with permission from AJCC: Neuroendocrine Tumors of the Appendix. In: Amin MB, Edge SB, Greene FL, et al., eds.: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer, 2017, pp. 389–94.
From: Gastrointestinal Neuroendocrine Tumors Treatment (PDQ®)
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