Table 3. Radiation Therapy Regimens used in Children’s Oncology Group AREN0532, AREN0533, and AREN0321 Protocols

Local/Locoregional Disease
Stage IStage IIStage IIIStage III (diffuse spill, peritoneal metastasis, preoperative rupture)a
Favorable histologyNo XRT No XRT10.8 Gy10.5 Gy
Focal anaplasia10.8 Gy10.8 Gy10.8 Gy10.5 Gy
Diffuse anaplasia10.8 Gy10.8 Gy19.8 Gy10.5 Gy + 9 Gy boost
Metastatic Disease
Stage IV Lung Stage IV Liver Stage IV Brain Stage IV Bone
Favorable histology10.5 Gy for age <12 monthsb,c; 12 Gy for age >12 monthsb,c 19.8 Gy +/- 5.4 to 10.8 Gy boostd21.6 Gy + 10.8 Gy boost for age <16 years; 30.6 Gy for age >16 years 25.2 Gy for age <16 years; 30.6 Gy for age >16 years
Focal or diffuse anaplasia10.5 Gy for age <12 monthsb; 12 Gy for age >12 monthsb 19.8 Gy +/- 5.4 to 10.8 Gy boostd21.6 Gy + 10.8 Gy boost for age <16 years; 30.6 Gy for age >16 years 25.2 Gy for age <16 years; 30.6 Gy for age >16 years

XRT = radiation therapy.

aRequires whole-abdominal XRT in 1.5 Gy daily fractions. Patients with diffuse unresectable peritoneal implants receive 21 Gy.

bWhole-lung irradiation is given in 1.5 Gy daily fractions.

cNot all patients receive radiation therapy.

dA boost is given for macroscopic disease.

From: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
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