| Stage | Histology | 4-Year RFS or EFS | 4-Year OS | Treatment (refer to Table 2 for chemotherapy regimen descriptions) |
|---|---|---|---|---|
| Stage I [93,133,134] | FH <24 mo/tumor weight <550g | 85% | 98% | Surgery including lymph node biopsy only (not standard treatment; should be done only in the context of a clinical trial) |
| FH >24 mo/tumor weight >550g | 94% RFS | 98% | Nephrectomy + lymph node sampling followed by regimen EE-4A | |
| FA | 68%a | 89% | Nephrectomy + lymph node sampling followed by regimen EE-4A and XRT | |
| DA | 68% EFS | 79% (n = 10) | Nephrectomy + lymph node sampling followed by regimen EE-4A and XRT |
DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy.
aFewer than five patients have survived 4 years; therefore, results should be interpreted with caution.
From: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)
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