| Stage | Histology | 4-Year RFS or EFS | 4-Year OS | Treatment (refer to Table 2 for chemotherapy regimen descriptions) |
|---|---|---|---|---|
| Stage III [93,133] | FH | 87% RFS | 94% | Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A |
| FA | 88% RFS | 100% (n = 8) | Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A | |
| FA (preoperative treatment) | 71% RFS | 71% (n = 7) | Preoperative treatment with regimen DD-4A followed by nephrectomy + lymph node sampling and abdominal XRT | |
| DA | 46% EFS | 53% (n = 16) | Preoperative treatment with regimen I followed by nephrectomy + lymph node sampling and abdominal XRT | |
| DA | 65% EFS | 67% | Immediate nephrectomy + lymph node sampling followed by abdominal XRT and regimen I |
DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy.
From: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)
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