From: Antineoplastons (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 3. Adverse Effects
| Adverse Effect | Reference |
|---|---|
| Anemia | [2,3] |
| Blood pressure elevation | [4,5] |
| Dizziness or vertigo | [6,7] |
| Excess abdominal gas | [4,8] |
| Fever and chills | [2,5-7,9-11] |
| General malaise with and without anorexia | [2,4] |
| Headaches | [1,4,6,7] |
| Hypocalcemia and hypercalcemia | [2,5] |
| Increased thickness of epidermis associated with skin peeling and faster-than-usual growth of nails | [11] |
| Maculopapular or itchy skin rash | [2,4,5,8] |
| Mild myelosuppression | [5,8,12] |
| Nausea and vomiting | [1,2,5-7] |
| Neurocortical toxicity, severe | [1]a |
| Numbness | [2] |
| Palpitations, tachycardia, or pressure in the chest with irregular heartbeat | [4,11 ,1,7] |
| Peripheral edema, facial edema, cerebral edema | [1,4] |
| Swelling, pain, or stiffness of small joints | [4,8,10,11] |
aThe most severe adverse effects occurred in this study, which reported neurologic toxic effects such as excessive somnolence, somnolence plus confusion, and increased frequency of underlying focal motor seizures; increased cerebral edema; and persistent confusion. In addition, the study reported myalgia, severe cutaneous erythema, pruritus, and anasarca of the extremities and face.