From: Genetics of Skin Cancer (PDQ®)
![Cover of PDQ Cancer Information Summaries](/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
MelaPRO [183] | MelPREDICT [182] | |
---|---|---|
Features of Model | Incorporates three different penetrance models | Uses logistic regression |
Can input information for large families | Accounts for a number of primary melanomas in family and age of onset | |
Includes information for unaffected individuals on risk of developing melanoma | ||
Limitations | The model has not been validated on unaffected probands. | Cannot incorporate complex pedigree structure information into the model |
Does not take into account domain-specific penetrances or geographical differences in penetrance |
From: Genetics of Skin Cancer (PDQ®)
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.