From: Genetics of Skin Cancer (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 7. Characteristics of Common Models for Estimating the Likelihood of a CDKN2A Pathogenic Variant
| MelaPRO [183] | MelPREDICT [182] | |
|---|---|---|
| Features of Model | Incorporates three different penetrance models | Uses logistic regression |
| Can input information for large families | Accounts for a number of primary melanomas in family and age of onset | |
| Includes information for unaffected individuals on risk of developing melanoma | ||
| Limitations | The model has not been validated on unaffected probands. | Cannot incorporate complex pedigree structure information into the model |
| Does not take into account domain-specific penetrances or geographical differences in penetrance |