From: Acute Myeloid Leukemia Treatment (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 1. Mixed Phenotype Acute Leukemia Diagnostic Criteria
| Diagnosis | Criteria |
|---|---|
| Myeloid Lineage | MPO (flow cytometry, immunohistochemistry, or cytochemistry) or monocytic differentiation (≥ 2 of the following: nonspecific esterase cytochemistry, CD11c, CD14, CD64, lysozyme). |
| T-cell Lineage | Strong cytoplasmic CD3 (with antibodies to CD3 epsilon chain) or surface CD3. |
| B-cell Lineage | Strong CD19 with ≥1 of the following strongly expressed: cytoplasmic CD79a, cCD22, or CD10; or weak CD19 with at least two of the following strongly expressed: CD79a, cCD22, or CD10. |
MPO = myeloperoxidase.