[Table], Table 6. Antiemetic Dosing for Radiation Therapya - PDQ Cancer Information Summaries - NCBI Bookshelf

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Table 6. Antiemetic Dosing for Radiation Therapy^a

Drug Category	Antiemetic	Dose	Comment	Reference
Serotonin (5-HT₃) receptor antagonists	Granisetron	2 mg PO daily		[14][Level of evidence: I]
	Ondansetron	8 mg PO or 0.15 mg/kg IV daily	bid–tid with TBI	[19][Level of evidence: I]
	Palonosetron	0.25 mg IV or 0.5 mg PO	Not studied in RT; no data available on frequency of administration	[28]
	Dolasetron	100 mg PO only		[11][Level of evidence: I]
Corticosteroids	Dexamethasone	4 mg PO or IV	During fractions 1–5	[23][Level of evidence: I]
Dopamine receptor antagonists	Metoclopramide	20 mg PO	prn during minimal-emetic-risk RT; inferior to 5-HT₃ receptor antagonists	[19][Level of evidence: I]
Dopamine receptor antagonists	Prochlorperazine	10 mg PO or IV	prn during minimal-emetic-risk RT	[28]

: 5-HT₃ = 5-hydroxytryptamine-3; bid = twice a day; IV = intravenously; PO = by mouth; prn = as needed; RT = radiation therapy; TBI = total-body irradiation; tid = 3 times a day.
: ^aAdapted from Roila et al.[3] and Hesketh et al.[28]

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