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Allen SJ, Wareham K, Wang D, et al. A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE). Southampton (UK): NIHR Journals Library; 2013 Dec. (Health Technology Assessment, No. 17.57.)

Cover of A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE)

A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE).

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List of abbreviations

AAD

antibiotic-associated diarrhoea

ABMUHB

Abertawe Bro Morgannwg University Health Board

ACE

angiotensin-converting enzyme

CDD

Clostridium difficile diarrhoea

CDDFT

County Durham and Darlington Foundation Trust

CDI

Clostridium difficile infection

CEAC

cost-effectiveness acceptability curve

cfu

colony-forming unit

CI

confidence interval

COPD

chronic obstructive pulmonary disease

CTA

clinical trial authorisation

EQ-5D

European Quality of Life-5 Dimensions

GP

general practitioner

HIV

human immunodeficiency virus

HRQL

health-related quality of life

ICER

incremental cost-effectiveness ratio

IMP

investigational medicinal product

IQR

interquartile range

ISRCTN

International Standard Randomised Controlled Trial Number

ITT

intention to treat

MCS

mental component summary

MedDRA

Medical Dictionary for Regulatory Activities

MHRA

Medicines and Healthcare products Regulatory Agency

NCIMB

National Collection of Industrial, Food and Marine Bacteria

NGT

nasogastric tube

NIHR

National Institute for Health Research

OR

odds ratio

PCS

physical component summary

PLACIDE

probiotic lactobacilli and bifidobacteria in antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in the elderly

PP

per protocol

PPI

proton pump inhibitor

PT

preferred term

QALY

quality-adjusted life-year

QoL

quality of life

RCT

randomised controlled trial

REC

Research Ethics Committee

RR

relative risk

SAE

serious adverse event

SF-12 v2

generic Short Form questionnaire-12 items version 2

SOC

system organ class

VAS

visual analogue scale

WCC

white blood cell count

Copyright © Queen’s Printer and Controller of HMSO 2013. This work was produced by Allen et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK261333

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