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Allen SJ, Wareham K, Wang D, et al. A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE). Southampton (UK): NIHR Journals Library; 2013 Dec. (Health Technology Assessment, No. 17.57.)
A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE).
Show details- AAD
antibiotic-associated diarrhoea
- ABMUHB
Abertawe Bro Morgannwg University Health Board
- ACE
angiotensin-converting enzyme
- CDD
Clostridium difficile diarrhoea
- CDDFT
County Durham and Darlington Foundation Trust
- CDI
Clostridium difficile infection
- CEAC
cost-effectiveness acceptability curve
- cfu
colony-forming unit
- CI
confidence interval
- COPD
chronic obstructive pulmonary disease
- CTA
clinical trial authorisation
- EQ-5D
European Quality of Life-5 Dimensions
- GP
general practitioner
- HIV
human immunodeficiency virus
- HRQL
health-related quality of life
- ICER
incremental cost-effectiveness ratio
- IMP
investigational medicinal product
- IQR
interquartile range
- ISRCTN
International Standard Randomised Controlled Trial Number
- ITT
intention to treat
- MCS
mental component summary
- MedDRA
Medical Dictionary for Regulatory Activities
- MHRA
Medicines and Healthcare products Regulatory Agency
- NCIMB
National Collection of Industrial, Food and Marine Bacteria
- NGT
nasogastric tube
- NIHR
National Institute for Health Research
- OR
odds ratio
- PCS
physical component summary
- PLACIDE
probiotic lactobacilli and bifidobacteria in antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in the elderly
- PP
per protocol
- PPI
proton pump inhibitor
- PT
preferred term
- QALY
quality-adjusted life-year
- QoL
quality of life
- RCT
randomised controlled trial
- REC
Research Ethics Committee
- RR
relative risk
- SAE
serious adverse event
- SF-12 v2
generic Short Form questionnaire-12 items version 2
- SOC
system organ class
- VAS
visual analogue scale
- WCC
white blood cell count
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