6J0D


Conserved Protein Domain Family
SUF4-like

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cd20908: SUF4-like 
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.
Statistics
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PSSM-Id: 411020
Aligned: 85 rows
Threshold Bit Score: 76.8263
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C H H C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:this domain contains two C2H2 type zinc fingers
  • Structure:6J0D: Oryza sativa transcription factor OsSUF4 binds 2 zinc ions; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #         #            #    #      #  #            #    #                    
6J0D_A         10 KVFCY-------YCDREFDDeKILVQHQKAKH----FKCHvCHKKLSTaGGXAIHVLQvHKESVTKv-PNAKPere--st 75   Japanese rice
XP_023991460  419 KHKCR-------FCAKVFCSdSSLQIHLRSHTgerpFKCNiCGNRFSTkGNLKVHFQR-HKEKYPHvqMNAYPip---dy 487  Arctic char
KAA8497928     22 RIFCY-------YCKRDFIDeQVLLAHQAQKH----FRCAtCGKRLASvKGLCVHSETlHRIVLKEv-PNAIQgrknids 89   Porphyridium ...
KJE98062       12 DTLCSdarmvdmYCERGFQDeTALIAHQRNTH----FQCKnCRKRLTTvPGLVRHCKIvHGYTLGHv-ENALPhks-rqv 85   Capsaspora ow...
GBG27189     1665 KPFCY-------YCDREFIDeNQLIQHQKARH----FRCLsCSRKFVSaPAMGVHLRQmHGQDLETv-PNALPgre--sp 1730 Hondaea ferme...
KAA0161408     15 PSICF-------YCMREFQDeTTLVAHQQARH----FRCVeCNRKLRTlSAMRHHLDGvHKVQLKRv-PNAKEghd--dp 80   Cafeteria roe...
CDQ72026      371 KHKCK-------YCGKTFGNdSGLQIHLRSHTgerpFKCNiCGNRFTTkGNLKVHFQR-HKEKYPHirMNPHPvp----e 438  rainbow trout
PXF47475       15 RIFCY-------YCDRTFHLeQELLSHQRDKH----LRCSvCSKRMISvQSMVVHAEQmHNTRIQTv-PNAVPgrd--si 80   Gracilariopsi...
XP_001316618    4 KVYCY-------FCNSSFDDeNQLISHQKSKH----FRCPiCSQVKQNlKSLNNHMLTlHRTYLEAv-PGAIEgrk--dp 69   Trichomonas v...
OHT16791        6 KVWCY-------FCDKVFDDeVHLINHQRMFH----FRCPiCRRQKMNcKLLVEHMSGvHKQILEKv-PNALEgkd--sp 71   Tritrichomona...
Feature 1                          
6J0D_A         76 EIEIFG-XQGIPPDVLA 91   Japanese rice
XP_023991460  488 SGIPYG-MSFLPEKPVA 503  Arctic char
KAA8497928     90 GVQVQG-MQGIPKSARK 105  Porphyridium purpureum
KJE98062       86 GLNITG-MAGVPPNDSD 101  Capsaspora owczarzaki ATCC 30864
GBG27189     1731 SVSVSG-MRGVPLHNPE 1746 Hondaea fermentalgiana
KAA0161408     81 NINCVG-MDGAPAWFMH 96   Cafeteria roenbergensis
CDQ72026      439 HLDNIPtSSGIPYGMSM 455  rainbow trout
PXF47475       81 TIEVLG-MKGIPDSYYA 96   Gracilariopsis chorda
XP_001316618   70 NVNIFG-LSGIPEDVYV 85   Trichomonas vaginalis G3
OHT16791       72 DNVVFG-MKGIPETEYV 87   Tritrichomonas foetus

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