2WML,2WNB


Conserved Protein Domain Family
GT29_ST3GAL1_2

?
cd23966: GT29_ST3GAL1_2 
beta-galactoside alpha-2,3-sialyltransferase 1 and 2
ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.
Statistics
?
PSSM-Id: 467694
Aligned: 19 rows
Threshold Bit Score: 387.406
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
?
Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2WNB: Sus scrofa sialyltransferase binds CMP and disaccharide, contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2WML_A        19 CTRCIEEqr---vsAWFDERFnrsxqplltaknahleEDTYKWWLRLQrekk---pnnlNDTIRELFQvvpgnvdp--ll 90  pig
2WNB_A        19 CTRCIEEqr---vsAWFDERFnrsxqplltaknahleEDTYKWWLRLQrekq---pnnlNDTIRELFQvvpgnvdp--ll 90  pig
NP_001027703  93 CGHQLDAsq----tRWFRARFnpeiepvwtqsaleidYLVYDWWLSLQssea---enldKTFEALYKEgvprkdpfarlt 165 vase tunicate
Q5TIN9        46 CNKCVMDln---deDWFFIRFnptvptllnrrnsamrSDVFEWWQGLQsdsq---kanfSDVVDILFSlfpdeehy---v 116 zebrafish
XP_002741496  64 RMPVWTKge----yKFFDDRYsnistiws-skhkemtPEALQWWLRIQqskdtfstsdlRNLVGKLLEiipdvmpy---a 135 Saccoglossus ko...
XP_002667882  42 CKDCVREks---hsTWFNELFdpsiqllltrgnyvlnKDVYKYWKGLQknkk---dsdyRAVVEKMFSlfpdktry---t 112 zebrafish
CDI70283      89 CPNIGTLlanpnlpRILKSKFhpdvkvmltqdtktldEPINSWWKKLQpfdn---krdfTELAEDLFTvipgen------ 159 Oscarella carmela
XP_002667813  53 CMERCLAas---edKWFTERFrrdvppllslcnstlpDHIYTWWQSLQsksk----tsyTKVIQELFTvvpgeghy---s 122 zebrafish
XP_022094494  74 CRRLWLKge----sLWFDLKFnaslsplwtqhnkklpTEVTLWWKTLQnski----dniSEVISAALQvipgddpy---h 142 crown-of-thorns...
XP_022102753 101 CKRAWQQgs----sSWFDRRYkesipalwtrrnrelrPEVREWWLSIHedgd----rdiPALLNSLFQivpdvdpy---p 169 crown-of-thorns...
Feature 1                     ###                    ##                    # #                  #
2WML_A        91 ekrlvsCRRCAVVGNSGNlkesyyGPQIDSHDFVLRXNkAPTEGfeaDVGsKTTHHFVYPESFRELaq---eVSXILVPF 167 pig
2WNB_A        91 ekrlvsCRRCAVVGNSGNlkesyyGPQIDSHDFVLRXNkAPTEGfeaDVGsKTTHHFVYPESFRELaq---eVSXILVPF 167 pig
NP_001027703 166 hdreagCRSCAVVGNSGNilnsnyGNVIDGHDFVIRMNkGPTYNyenDVGsKTTHRFMYPTTAASSlp--qgVSLVLVPF 243 vase tunicate
Q5TIN9       117 vtdpnrCRICAVVGNSGNilgshyGQLIDSHDFVIRINkGPTKGyetDVGsKTTHRIMYPESAMDLdn---sTHLVLLPF 193 zebrafish
XP_002741496 136 tnvsnrCLQCAVVGNSGNlrdsryGQLIDSHDYIMRMNtAKTVGfekDVGsRTTHHFMYPESFVEVig---eTKFVLIPF 212 Saccoglossus ko...
XP_002667882 113 naspnrCRTCAIIGNSGNlkgsryGRLIDAHNFVIRINmGPTKGyedDVGsKTTHRFIYPESAVDFdn---sTYLVLSPF 189 zebrafish
CDI70283     160 pfspgvCRRCAVVGTAGRlkgarqGKLIDSFDIVIRMNrSPVKGyevDVGsKTSYHLVYPESAVGYrgaessGKLVLFPF 239 Oscarella carmela
XP_002667813 123 dagpdrCRTCAVVGNSGNllgtkyGKLIDNHDFVFRMNkAPIKGyekDVGsRTTHRIMYPESATHLdn---sTHLLLVPF 199 zebrafish
XP_022094494 143 mrdvsrCLRCAVVGNSGNlrnsnyGKLIDAHDFVFRINkAPMAGfssDVGsKETHRFMYPESFLNPrp---nVNFVLMDF 219 crown-of-thorns...
XP_022102753 170 krnldrCVRCAVVGNSGNlrhsgyGALIDSHHRIIRVNyAPIQGyedDVGsRETHRIAYPVTYTEVqk---gAHFVLVPF 246 crown-of-thorns...
Feature 1                                                                  # ###                 
2WML_A       168 KttDLEWVISAttTGRISHtyvPVPAKIKVKkEKILIYHPAFIKYVFDRWlqg--hgRYPSTGILSVIFSLHiCDEVDLY 245 pig
2WNB_A       168 KttDLEWVISAttTGRISHtyvPVPAKIKVKkEKILIYHPAFIKYVFDRWlqg--hgRYPSTGILSVIFSLHiCDEVDLY 245 pig
NP_001027703 244 QplDIKWLLSAltTGEITRtyqPLVRRVTCDkSKITIISPTFIRYVHDRWtqh--hgRYPSTGLLALIYALHeCDEVDVY 321 vase tunicate
Q5TIN9       194 KvkDMQWLISVftTKHITStylKVRPTINADrEKVMIIHPAFIKYVYESWlrk--hgSYPSTGFITLIFALHiCDQVSVF 271 zebrafish
XP_002741496 213 KplDVSWLISAltTGTIVRtymPVRKQINVSkKMIEVYNPAFMYYVHKTWnel--hgRYPSTGMLVLLFAMHiCDQVNVF 290 Saccoglossus ko...
XP_002667882 190 KvlDIEWLISSftTKNITRtykKVRASINANrHKVMILHPAFIKYVHEIWlvk--hgKYPSTGFLAIIFALHiCDQVSTF 267 zebrafish
CDI70283     240 KvlDIEWLKSIftTHPISKgwtHLPTNLGLKpTDAMVIHPEFIYYVAKTWleg--kgRWASAGALSVVWALHiCNEVDVF 317 Oscarella carmela
XP_002667813 200 KtlDLQWLTSTltNGTIKRtrmKVINKLQADkNKVMVMHPAFMHYVHNTWlhikarrSYPSTGILVLIFALHiCDQVSVF 279 zebrafish
XP_022094494 220 KllDVAWLTSAltNGTITRtytTVKKSISVSrDKVMIYNPALMHHVHTEWtqk--hgRYPSTGHLALFFALQiCDEVDLF 297 crown-of-thorns...
XP_022102753 247 GakDIDWLISAltNGTITWtysPVPRFIDVDrSKVQVFNPTLMYDSKFSWigd--eeRWPSTGFLMILFAFHiCDEVNIF 324 crown-of-thorns...
Feature 1        ###      ###                    ##                      
2WML_A       246 GFGadskgNWHHYWENNpsaga-----frktgVHDGDFESNVTTILasiNKIRIFK 296 pig
2WNB_A       246 GFGadskgNWHHYWENNpsaga-----frktgVHDGDFESNVTTILasiNKIRIFK 296 pig
NP_001027703 322 GFGanragNWHHYWEDLpphvag---afrktgVHDSAQENEIIDQLhihGLLRVHR 374 vase tunicate
Q5TIN9       272 GFGakldgNWHHYFDESlahf--------nrgRHGGDYENRTIHKLllmNKIALHK 319 zebrafish
XP_002741496 291 GFGatskgNWDHYYQPPvepslekdsafkltgVHNAEFETDIVKQLeeiGKITVYR 346 Saccoglossus kowalevskii
XP_002667882 268 GFGadqygNWYHYFEKTssrv--------rtgAHSGSFEFDTMMQLyleSKIRVFR 315 zebrafish
CDI70283     318 GFGankygNWDHYYEKFsskekd---pfrrtgVHDANIEETVRMELhkeKIIRFHP 370 Oscarella carmela
XP_002667813 280 GFGanskgYWYHYFEKMpkff-------wrtgLHSGGIEHDVIKELqkrKLIDLYK 328 zebrafish
XP_022094494 298 GYGanklgNWDHYWKKDdgthns---ffkktgVHDSNFEQSIMENLrkaDKIKIYP 350 crown-of-thorns starfish
XP_022102753 325 GFGassygAWDHYWEPDaglwnii--yksmfsPHNHSVEETILEKWnkeGKVKIFR 378 crown-of-thorns starfish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap