2WGP


Conserved Protein Domain Family
DUSP14

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cd14572: DUSP14 
dual specificity protein phosphatase 14
dual specificity protein phosphatase 14 (DUSP14), also called mitogen-activated protein kinase (MAPK) phosphatase 6 (MKP-6) or MKP-1-like protein tyrosine phosphatase (MKP-L), functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). It deactivates its MAPK substrates by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. DUSP14 is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. DUSP14 dephosphorylates JNK, ERK, and p38 in vitro. It also directly interacts and dephosphorylates TGF-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1) in T cells, and negatively regulates TCR signaling and immune responses.
Statistics
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PSSM-Id: 350420
Aligned: 6 rows
Threshold Bit Score: 292.156
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:2WGP: Human DUSP14 binds a phosphate ion in the active site; contacts at 4A
  • Comment:also based on the structures of some DUSP family members with bound phosphorylated substrates (peptide and non-peptide)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #                                         #                   
2WGP_A        19 SEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS 98  human
XP_415902     20 SEGALGGIAQITPSLYLSRGSVASNRHLLLSRGITCIINATIEIPNFNWPQFEYVKVPLADMPNAPISLYFDSVADKINS 99  chicken
NP_001006060  43 ATSLLGGIAQITPSLFLGRGNVASNRSLLLSKGITCVVNATIELPNFNWPHMEYVKVPLADMPHSPISLYFDSVADKIHS 122 zebrafish
NP_001086177  30 SVSSLSSIAQISPCLYLSSGNAAGSRHLLYSRNVTCIVNATLEIPNCNWPDVDYMKVPVPDLPHAPLALYFDSVADRIHQ 109 African clawed ...
O95147        20 SEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS 99  human
XP_005987506  20 SDGVLGGIAQITPSLYLSRGNVASNRNLLLSRGITCIVNATIELPNFNWPQFEYVKVPIADMPHAPISLYFDSIADRIHN 99  coelacanth
Feature 1                   #######                                                    
2WGP_A        99 VSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNvGFWRQLIDYERQLFGKS 168 human
XP_415902    100 VARKHGATLVHCAAGVSRSATLCIAYLMKYHKVSLFEAYNWVKSRRPVIRPNvGFWRQLIDYERKLFGKT 169 chicken
NP_001006060 123 VGRKRGAVLVHCAAGVSRSASLCLAYLMKYHRVSLAEAHAWVKARRPVIRPNgGFWRQLIEYERKLFGRN 192 zebrafish
NP_001086177 110 NGKRNGRTLVHCVAGVSRSATLCIAYLMKYHRLALLDAYQWVKTRRPVVRPNmGFWQQLIQYEKKLFGKN 179 African clawed frog
O95147       100 VSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNvGFWRQLIDYERQLFGKS 169 human
XP_005987506 100 VTKKHGATLVHCAAGVSRSASLCIAYLMKYHKVSLLEAYNWIKSRRPIIRPNvGFWRQLIDYERKLFGKS 169 coelacanth

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