3FWK,2WSI


Conserved Protein Domain Family
FAD_synthase

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cd23948: FAD_synthase 
FAD synthase
FAD synthase (FMN:ATP adenylyl transferase (FMNAT); FAD pyrophosphorylase; Flavin adenine dinucleotide synthase (FADS); EC 2.7.7.2) is involved in the biochemical pathway for converting riboflavin into FAD. By sequence comparison, bacterial and eukaryotic FMNAT enzymes belong to two different protein superfamilies and apparently utilize different sets of active-site residues to accomplish the same chemistry. This subfamily includes eukaryotic FMNATs, which are members of the 3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase-like family belonging to the adenine nucleotide alpha hydrolase superfamily, which has conserved motifs different from those of nucleotidylyl transferases.
Statistics
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PSSM-Id: 467513
Aligned: 62 rows
Threshold Bit Score: 207.759
Created: 24-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
FAD bindingPP-loop
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Structure:2WSI: Saccharomyces cerevisiae FAD synthetase binds FAD, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 ###   ##                                      ###      
3FWK_A        39 INTTKSILINETFPKWsplnGEISFSYNGGKDCQVLLLLYLSCLweyyivklsqsqfdgkfhrfpltkLPTVFIDHdd-- 116 Nakaseomyces gl...
2WSI_A        34 IRLTRKYLLSEIFVRWsplnGEISFSYNGGKDCQVLLLLYLSCLweyffikaqnsqfdfefqsfpmqrLPTVFIDQee-- 111 Saccharomyces c...
CCW62440      25 FVVDAKEIILNTCKFFp--lHEIGVSFNGGKDCVVVVELIREVLglea-----------------lkqVIFFFLENpe-- 83  Phytomonas sp. EM1
OHT03313      16 KIESSLGIIASAYEQYr---KELGVCFNGGKDSVVLLDLVQRFHeenk----------------cdfpMNSFFFKSph-- 74  Tritrichomonas ...
XP_001318864  10 KILSAKSVIKEAFERYs---DKLSFCYNGGKDSVVLLDLVMNVVken------------------nytIKPFYLEVgd-- 66  Trichomonas vag...
NP_727648     71 RQNKAFAFFAETLQIYg--vEELIFCFNGGKDCTVLLDLLMRYLrqeni---------------ssgdIPMLYIKSgd-- 131 Drosophila mela...
XP_001582281  22 KIAITSKVLKLAYADHg---PEIGLCFNGGKDSSVVLDLVRRFHesak----------------istpVRPFFIKEkn-- 80  Trichomonas vag...
XP_828820    117 LVKESIDVVKGIVSQFk--pEEIGIAFNGGKDSVVMMDILYCVMgae------------------fisQCCVFHLNtind 176 Trypanosoma bru...
KPI88315      43 HVQVSHAIIRDVFDRFp--aSEIGISFNGGKDSVVMLDLIRRIIpvdll---------------kqccMFVIDLRDe--- 102 Leptomonas seym...
CUF99518      21 AIDSARDVIQTCFGRFp--iEAIGISFNGGKDSVVMMELLIAHVgadk----------------vakcHIFMFGEDd--- 79  Bodo saltans
Feature 1                                           #   #            # ###  #                    
3FWK_A       117 -tFKTLENFIEETSLRYs--LSLYESDrdk--cetMAEAFETFLQVFpetkAIVIGIRHTDPFGEhlk-piqKTDANWPD 190 Nakaseomyces gl...
2WSI_A       112 -tFPTLENFVLETSERYc--LSLYESQrqsgasvnMADAFRDFIKIYpeteAIVIGIRHTDPFGEalk-piqRTDSNWPD 187 Saccharomyces c...
CCW62440      84 seFLEMEQFRNKYFKERlpgITLHKIDsr----dgMLQGLWRVKRQFgi-kASFMGTRRDDLSQPpsf-pwePNTVEWPT 157 Phytomonas sp. EM1
OHT03313      75 -eFPEMAEYVKNAENYWkqnFRVIESAs-------LQQGLSTIVDKYgv-nAIFLGVRQSDPKGGnll-pftPTTEGWAD 144 Tritrichomonas ...
XP_001318864  67 -eFDEILDFINYSEKYWg--FKLMRIKat-----nLKEGLEKLINTYqi-nSVFLGVRADDYPNIkmk-pfePTNNGWPE 136 Trichomonas vag...
NP_727648    132 -sFPEIDEFVERCVRNYr--VQLVQYEg------tLKEALTHMSSDMprikAVFVGSRNTDPYCQhla-pmqPTDNDWPP 201 Drosophila mela...
XP_001582281  81 -dFPEITEFVKQTEERIg--VTIRKVQsd-----sIKNAIEKIVEEDri-ySFFLGQRKTDPNCSnik-efnLTSDDWVH 150 Trichomonas vag...
XP_828820    177 keFHEVVEFRKAFAAARk--LSIVQSDqm----lsMKDGLEQVKKTMgi-rVAFMGTRKADGCHQmtg--veRTTAGWPD 247 Trypanosoma bru...
KPI88315     103 --FDELLDFRARYMREEakeLTLRHQEvt----mdMRESMFKLLAKWpl-kAVFMGTRKTDPHGRsqhspveMTTVGWPE 175 Leptomonas seym...
CUF99518      80 -eFDDIRSFRESYLAHR---LPAAVLHtlpq-qygIKGGLEVLRNEHnl-eAVFIGTRKDDPSAKyqktsmePTTAGWPQ 153 Bodo saltans
Feature 1        # #                                            
3FWK_A       191 FYRLQPLLHWNLANIWSFLLysnEPICELYRYGFTSLGNVEETLPNP 237 Nakaseomyces glabratus
2WSI_A       188 FMRLQPLLHWDLTNIWSFLLysnEPICGLYGKGFTSIGGINNSLPNP 234 Saccharomyces cerevisiae
CCW62440     158 MLRVYPILHWSYRNVWNYILsanVPFCVLYSYGYTSLGDCRSTYKNS 204 Phytomonas sp. EM1
OHT03313     145 AMRIFPLLEWEYSDIWEYLDvmkLPICDLYKRGYTSIGSPATTKPNP 191 Tritrichomonas foetus
XP_001318864 137 AERIMPILDWTYNDIWEYIDkfnLPFCSLYNLGYTSIGPKSKTHPNP 183 Trichomonas vaginalis G3
NP_727648    202 MMRLNPLLEWSYHDVWHYIHlnsVPYCSLYDRGYTSIGNRANTVPNP 248 Drosophila melanogaster
XP_001582281 151 AMRIFPILNWAYKDIWEYIDaleLPVCSLYSKGYTSIGNTKNTIPNP 197 Trichomonas vaginalis G3
XP_828820    248 LLRACPLFCWEYEDVWGYIRtydLPFCELYEKGYTSLGGANSTIPNS 294 Trypanosoma brucei brucei TREU927
KPI88315     176 FYRVCPLFSWSVHHVWEYTKlnhIPQCKLYEDGYTSLGSVSNTSRHP 222 Leptomonas seymouri
CUF99518     154 MMRYCPVFNFCYHEVWMYIAthqVPVCKLYACGYTSLGRIALTVPNQ 200 Bodo saltans

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