Conserved Protein Domain Family
BORCS7

?
pfam16088: BORCS7 
BLOC-1-related complex sub-unit 7
This is a family of unknown function found in eukaryotes. Family members include BORCS7 (BLOC-1-related complex sub-unit 7) also known as Diaskedin (from the Ancient Greek 'diaskedazo', meaning 'to disperse') or C10orf32. It constitutes sub-unit 7 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.
Statistics
?
PSSM-Id: 465012
Aligned: 20 rows
Threshold Bit Score: 78.5028
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003288841   5 FSRSRATSSSASV---------DPAvikKKELT-ELGEKIINDIGKATKSMIKHSNVHDNMMIISKSFAAHEGNIAQT-- 72 
EFX71566       1 MASASSSSAKLLY---------GDS---KARIN-QRVRYTIDGIGSLSRNLVRSSKSSETLMQSAKLTSQQEHILEAA-- 65 
3_pfamImport   1 MNSNLPPNTA------------------KLQLA-NSSQVNVSDITTVVNQILKGSNSAVILGKAQQNLVTSETNINSS-- 59 
Q4V8S9         1 ---mASSETQPRF---------GQSv--KGLLS-DKVTSCSGDVIALTRQVLKGSRSQELLSQAARNMVIQEDAILHS-- 63  zebrafish
2_pfamImport   1 MALTTTPFIQRMF---------VQAl--KDILTaEKVNVCGTDVIVL----IKGSWNSELLRQVARNIVLQEDAILHS-- 63 
XP_001959003   1 MASASSSSARHLF---------DDS---KKRLC-ARVGVNVNNLGSVARQVVRGSKTNEIMHQTLKNFTQVDVVSDYS-- 65 
EFA85222       1 MSQTYSNSGSASLvtassthieDPSlgvKKELT-ESGEVIITELGKSIKSLIKHSN---NMLAICKAFAQHEVNVMQT-- 74 
EGF80085       1 -MVLHSSNKHTLL---------QES---KAELT-TTATDIFSQWSAIGKAVVRSSNSSDATQKAIKSFVATDDALDRTck 66 
EPB90343      14 srassiHEDQQQF---------FAS---KEECH-LKTGKAFDDWEYVIKALSKTSQVHDDTLKTAKLFTQVDALSKNT-- 78 
XP_008188126   1 MTSASSTSARSLF---------GDS---KNLLS-ERVKLNINNMSSVIKQIHRSSKSHEMLNQTVKSLAFLESNIDRT-- 65 
XP_003288841  73 --EELIKQMSAL------S-KELSNQVGLLQSSLDSMEPLNNNIVNT 110
EFX71566      66 --DLSLRKMQVL------V-THLGYQLESIESNAKAFADVREQFQGL 103
3_pfamImport  60 --VQTFHKLSAL------V-THLNYQQEAITKSIKQTELVTAQLGGI 97 
Q4V8S9        64 --EDSLRKMSII------T-THLQYQQEAIQKNVEHSKNLQDQLRHL 101 zebrafish
2_pfamImport  64 --EESLREMAVT------T-THLHCQQEAV-KNVQRSSDLQDQLKHL 100
XP_001959003  66 --HQNLQKMNLI------L-QHVNYQYEVMHDSVNHLDYLKEQVTAM 103
EFA85222      75 --DDMINQMNSL------S-KELNQQVNILSNSLKCLDSINYAVVDV 112
EGF80085      67 nlDRSLDELTLLlrgtvdThRLLEIGVKDVHRGIQGVIGVESAANSI 113
EPB90343      79 --KNSIEKTSKT------L-DRLLDKKLGILAAVKSFNDIQSSLDvt 116
XP_008188126  66 --EHNLNQLRNV------S-TNFNQQYGEFKRSIQLIEEVKEHVQTM 103
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap