4AYA


Conserved Protein Domain Family
bHLH_dnHLH_ID2
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cd19692: bHLH_dnHLH_ID2 
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basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins
ID2, also termed Class B basic helix-loop-helix protein 26 (bHLHb26), or inhibitor of DNA binding 2, or inhibitor of differentiation 2, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.
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Statistics
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PSSM-Id: 381535
Aligned: 8 rows
Threshold Bit Score: 132.061
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:HLH region of bHLH forms homo- and heterodimers
  • Structure:4AYA; Homo sapiens ID-2 forms a homodimer, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #  ##  ## ##  #           ##  ## ## ### ##  #   #
4AYA_A        19 HSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHL 84  human
Q6PBD7        18 HSLGIARSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQLALDSHP 83  western clawed frog
Q02363        18 HSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHP 83  human
NP_990333     18 HNLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHP 83  chicken
NP_958448     22 HSLGISRSKTPVDDPLSLLYNMNDCYSKLKELVPSIPQNKNVSKMEILQHVIDYILDLQIALDSNS 87  zebrafish
XP_006001443  19 HSLGISRSKTPVDDPMNLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQFALDSHS 84  coelacanth
XP_007904657  25 QSLGISRGKAPVEEPLGLLYNMNDCYSKLRELVPSIPQNKKVSKMEILQHVIDYILDLQIALDTHP 90  elephant shark
Q9PWJ5        18 HSLGIARSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQLTLDSHP 83  African clawed frog

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