Conserved Protein Domain Family
Tmp39

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pfam10271: Tmp39 
Putative transmembrane protein
This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.
Statistics
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PSSM-Id: 463038
Aligned: 13 rows
Threshold Bit Score: 481.536
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5U2V9               42 AIGLPVPPTtALITPGPvRHCQIPDLP-VDGSLFFEFLFFIYLLIVLFIQYINIYKTVWWYPYNHpaSCTSLNFHLIDYY 120 Norway rat
EKC27988             30 DRDTNMVPL-AQMAVLP-KHCHLPEIP-SDPNMSFEAMLYFFGVIAMGLQYINLYRTVWWLPHSH--ANYALNFYLIDVY 104
EFO84726             15 ATVTVPPPRtSGVTLS--VHPIWPDIQfTQGELFFECTLFLYSVLALFLQYLNIYKTLWWLPKSY--WHYSLKFHLINPY 90 
XP_001959491         26 KPGQAQTPA----TAMP-KHIPFPDHA-TTSEWLSELIMCAFTMGSAIVQFINIYRTNWWLPQAH--TRHMVNIDLIDPH 97 
WGS:AAQB:GK10634-PA  29 GPNPSIMPI----SILP-KHIQFPDHS-STTECLSELIMSAFTMGAAIVQFINIYRTNWWLPQSF--TKHLVNIELIDPY 100
EDO41973             64 SIGTVRQTIsSLLTIPQlYHIPIPRVP-IFNAMGFEILFFAYLVSALGLQYLNIYK---------------LNFHVVDVH 127
NP_955926            42 AVGLSAPPLtALITPEPvRHSRIPDLP-LDSNLLFETLLLLYLLVALLVQYINIYRTVWWSSYSQptASTSLNFHLMDAH 120
XP_006639253         42 SVGLSAPPItALITPEPvRHSRIPELP-LDGSLLFEFLLFTYLLVALFVQYINIYKTVWWYPYSHpaASTSLNFHLIDYH 120
Q7ZW11               48 GTGMSSPPL-ATQTVVPlKHCKIPELS-MDKNVLFELHLFACHLIALFVHYVNIYKTVWWYPPSHppSHTSLNFHLIDYN 125 zebrafish
1_pfamImport          1 STGLSSPRL-AAQTVVPlQHNKIPELP-MEKSVLFELHLLFCHLIALFVHYVNIYKTVWWYPPSHppSHTSLNFHLIDYN 78 
XP_005317795         48 GTGLSSPPL-ATQTVVPlQHCKIPELP-VQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHppSHTSLNFHLIDFN 125
OCA45307             47 STGLSSPPL-ATQTVVPlRHCKIPDLP-ADRHLLFELQLFFCHLIALFVHYINIYKTVWWYPPSHppSHTSLNFHLIDFN 124
Q6DF19               47 STGLSSPPL-ATQTVVPlRHCKIPDLP-ADRHLLFELQLFFCHLIALFVHYINIYKTVWWYPPSHppSHTSLNFHLIDFN 124 tropical...
Q5U2V9              121 LAAFITVMLARRL---VWALISEATKagaASMVHYT--ALILARL---VLLTLCGWVLCWTLVN--------LFRSHSVL 184 Norway rat
EKC27988            105 LVLFLCILMSRRI---VWCFVQEVYG---SRFSKSV--LFWVVQFlkgALLGSIALGLVYTAYM--------VVANHSAL 168
EFO84726             91 FLSCVGLLLGWRVtvcFWKTITEVIAaisANQSQFVqsSLMIVEY---AAIKTPVMTLIITSFLfsfnrvchDFPSRSVL 167
XP_001959491         98 LRYLLFILNTRRL---IYCLLL-IKIrkfDENTQNW--IRLGVKY---GFGGLVQLGLGFCAVK--------LYQQHTYI 160
WGS:AAQB:GK10634-PA 101 LRYFILILNTRRF---LYSVLV-VKWr-----hRYW--IRLGVKY---GFGGFVQLLLAYCAWR--------LYQKHSLL 158
EDO41973            128 LVTFILIFLSRRL---IWNILKQTLA--------SE--ILFTVKYflgLIFKAVIFLVVICTLTwll---wkLFQHNSIQ 191
NP_955926           121 LAVFIAVMLSRRL---VWTLLSEVCVacpASPLCYV--LLLVVRV---CVLTLCGWVLCWTLLN--------LFRSHSVL 184
XP_006639253        121 LATFITVMLARRL---VWTIISEASQtgpTSVVRYT--VLIAARL---TLLTLCGWVLCWTLVS--------LFKNHSVL 184
Q7ZW11              126 MLVFTVIVLARRL---IAAIVKEASQsgkLSFPHSV--FLVTARF---AVLTLAGWSLCRSLIY--------LFKTYSVL 189 zebrafish
1_pfamImport         79 LLTFTTVVLARRL---VSAIVKQASQngkVHLPQSV--FLVTIRF---VVLTGTGWSLCRSIIY--------LFRTYSVL 142
XP_005317795        126 LLMVTTIVLGRRF---IGSIVKEASQrgkVSLFRSI--LLFLTRF---TVLTATGWSLCRSLIH--------LFRTYSFL 189
OCA45307            125 VLTLTTIVLARRL---IGAIVREASQggkSSVPHSL--LLVATRF---AVLTGTGWSLCRSIIL--------LFRTHSFF 188
Q6DF19              125 VLTLTTIVLARRL---IGAIVREASQggkSSVPHSL--LLVATRF---AVLTGTGWSLCRSIIL--------LFRTHSFF 188 tropical...
Q5U2V9              185 NLLFLGYPFGVYVPLYCfhqdsrahlllTD--YVVQHQAvEDAASNVGSLTR-SKDFLSLLleslkeqf----nnstpip 257 Norway rat
EKC27988            169 YCLFLSCPVITYVFLFG-----------PSikPLYHRCLvWPTSVCDRPRHKkEEEEVILF------------------- 218
EFO84726            168 WFLF---PVFFYVFIF----------------RSEIIGWlRKFRELVGKWRRkESDFSTICerltesppa---qidldsv 225
XP_001959491        161 LLLFLSYPVIIYLFIFGfq---------------------------lePFLR-TRFELpgvyi-------------ndmp 199
WGS:AAQB:GK10634-PA 159 LLFYLSYPVLVYLLIFGfq---------------------------lePFLR-TRFELpgvyi-------------ndlp 197
EDO41973            192 NCLFLLYPIVMYLCAFGftld----------------pqgNKVMFKISPHVEiSQIHLIPTrtmekkafqngdarqelig 255
NP_955926           185 KLLFLGYPFGVYVPLCClhqd---gspaADcgFADADGA-------DGALLQ-PRDFLTLLrenlrqqls---gththth 250
XP_006639253        185 NLLFLGYPFGVYVPLCCfhqesrtqtlpADcgYLEQEQM-------DGPLLR-PKDFLTLLrenlreqf----nsptsip 252
Q7ZW11              190 SLLFLCYPFGMYIPFFRlscd---frraGSmsPLSGIGSkDVG---AAALGRgGRDYLSVLketwkqhtsq-lysaqpmp 262 zebrafish
1_pfamImport        143 NLLFLCYPPKVHLPHRQwylaasplgfsTSlrLTTVSIVqRMTPFCSAWLRSrNRLYF---------------------- 200
XP_005317795        190 NLLFLCYPFGMYIPFLQlncd---lrktNLfsHMASVGPrEA----VSGLAR-SRDYLLTLretwkqhtrq-lygpeamp 260
OCA45307            189 NLLFLCYPFGMYIPFLQlgwdf--rrpgLS--HMPNTRD-------LASMDRgSKDYLHVLqhilrhhm----psaeplp 253
Q6DF19              189 NLLFLCYPFGMYIPFLQlgwd----frrPGlsHMPNTRD-------LASMDRgSKDYLHVLqhilrhhm----psaeplp 253 tropical...
Q5U2V9              258 tHSCPLSPDLI-RNEVE---CLKADFNHRIKDVLFNS----------LFSAYYVAFLPLCFV-KST-------QYYDMRW 315 Norway rat
EKC27988            219 -HNCVLTPDVI-RSEVE---YFKLDFNNRIKQVLFNS----------LLTAYYMTFVPLCFA-QNT-------LYYDTWW 275
EFO84726            226 lHMCSDNPAQI-REEIQ---VLIDDLVLRVKKSIFAG----------VSTAFLSIMLPCIFVpYKTsqgipqkILINEFW 291
XP_001959491        200 vHSCTTNAVHI-RDEVE---TLRHDFNRRFKQLIFTS----------MLNAYYSGLVPCCLA--VS-------VQYNVIR 256
WGS:AAQB:GK10634-PA 198 vHSCTTNPQQI-REEIE---TLRHDFNKRFKQLIFTS----------MLNAYYSGLVPCFLA--MS-------INYNVMR 254
EDO41973            256 kPNCTLPPDAV-RYEAE---CLRTDFNSRIKQVLFQS----------LLCAYFVGFLPMRFSeQHH-------VYYDLWW 314
NP_955926           251 tHTCPPSPELI-RSEVQ---QLKTDFNRRIKEVLFNS----------LLSAYYVAFLPLCFV-KST-------QYYDMRW 308
XP_006639253        253 aHTCPLSPDLI-RNEVE---CLKADFNRRIKEVLFNS----------LFSAYYVAFLPLCFV-KST-------QYYDMQW 310
Q7ZW11              263 tHACCLSPDLI-RKEVE---YLKMDFNWRMKEVLVSS----------MLSAYYVAFVPVWFV-KST-------QYVDKRW 320 zebrafish
1_pfamImport        201 --QISLTPAFCyRSKLNarlLLRLSLDFSFKNILGCSpikfeprilfLVECFVSSLCSPRFVgERT--------FYEMYK 270
XP_005317795        261 tHACCLSPSLI-RSEVE---FLKMDFNWRMKEVLVSS----------MLSAYYVAFVPVWFV-KNT-------HYYDKRW 318
OCA45307            254 tHACCLSPDLI-RSEVH---YLKLDFNWRVREVLLSS----------MLSAYYVAFVPVWFV-KST-------QYYDKRW 311
Q6DF19              254 tHACCLSPDLI-RSEVH---YLKLDFNWRVREVLLSS----------MLSAYYVAFVPVWFV-KST-------QYYDKRW 311 tropical...
Q5U2V9              316 SCEHLIMVWINAFVMLTTQ--------LLPSKYCDLLHKSAAHLGKWQKLe---HGFYSNAPQHI---WSENTIWPQGVL 381 Norway rat
EKC27988            276 VGQHVVVTWLSAFLMLIVH--------YLPPKYLDLLHRTALHLGRWQKV----EGRHAHVPYNA---WSELTVWPPGAL 340
EFO84726            292 ECQLGIVVGLTAFSLYVAY--------LSPLNYLDLLHRAAIHLGSWRQIegprIGHTGSMISAPt-pWNEFCLYNDGET 362
XP_001959491        257 AAQHCLGVCLGAFSLCAVF--------LYPAKYSDTLHRATLHLGCWQRIg---TVPVQLIAAANaptWSKYSSYGHGTV 325
WGS:AAQB:GK10634-PA 255 AAQHCIIVCLGAFSLSFVF--------LYPARYSDILHRATLHLGCWHRMdaadPNPSQLILAANaytWSKYLIYPQNTV 326
EDO41973            315 ACQQILFIWLSSLLVLMMY--------MLPLTYCDALHKCAVHLGGWERYt---CG-HRETP-HV---WSPLTVWPQGVL 378
NP_955926           309 SCEHLIMVWINAFVMLMSH--------LLPPHYCDLLHRCAAHLGRWQRLe---PGSCSNTPQHT---WSDSTIWPQGVL 374
XP_006639253        311 SCEHLIMVWINAFVMLMSQ--------LLPPKYCDLLHRSAAHLGKWQKLe---HGSYSNAPQHV---WSENTIWPQGVL 376
Q7ZW11              321 SCELFILVSVSTSVILMRH--------LLPPRYCDLLHKAAAHLGCWQKVd---PSLCSNVLQHI---WTEEYMWPQGVL 386 zebrafish
1_pfamImport        271 MTTFCVLVIICKLRLLLASgaqdgdsvRHPASSPETEHKVMTSC---------------NTIKKClhrWSEEYMWPQGVL 335
XP_005317795        319 SCELFLLVSISTSVILMQH--------LLPASYCDLLHKAAAHLGCWQKVd---PALCSNVLQHP---WTEECMWPQGVL 384
OCA45307            312 SCELFLQVSLSTSVILTQH--------LLPARYCDLLHKAAAHLGCWQKVd---PALCSNMLQHS---WMEECMWPQGVL 377
Q6DF19              312 SCELFLQVSLSTSVILTQH--------LLPARYCDLLHKAAAHLGCWQKVd---PALCSNMLQHS---WMEECMWPQGVL 377 tropical...
Q5U2V9              382 VRH-SRCLYRAMGPYNV----AVPSDGSHARFYFLFHRPLRVLNLLILIEGSVIIYQLYSLLRSE-KWNHTLSMALVLFC 455 Norway rat
EKC27988            341 VKH-VKGLFKAEGINVT----AEPGNGMHGRFFFLFHQPMRVVNWLLILTWLLVGYQFFCLIQST-EWNHIVCIALVLFC 414
EFO84726            363 VQMpDGRCYRAKASHLIrtvaAHPESSRHNTFFRVLQRPHYLINAMCTFEFVLIFIQFWMLVLTN-DWQHIVTFVLLMFA 441
XP_001959491        326 VKH-NGGLYRSHGVVTV----ATPGNTSHARFYKLFHNPTTIYSTLAILQAAVLLVEIGSLSAESvEWHFVLSISFVAFT 400
WGS:AAQB:GK10634-PA 327 VKH-NGGLYRSQGPVTV----AMPGNGSHVRFYKLFHNPTVIYSTLATLQAAVLLVEIASLSSTSiEWHFVLSISFVAFT 401
EDO41973            379 VRH-NKLLYKGLGIHNV----AIPGDPHHSRFFFMFESPLRLINWMSASLLALVLYQLVLIIRCH-FWYQLLSVVGMLSF 452
NP_955926           375 VRH-SRCLYKAVGPYNV----ALPSDVSHARFYFLFHKPLRLLNVLIGIECSVVVYQLYSLLRSE-RWNHTLSLGLILVC 448
XP_006639253        377 VRH-NRCLYKAVGPCNV----AVPSDVSHARFYFLFHKPLRILNLLILIEGSVVLYQLYSLLRSE-KWNHTLSLALILFC 450
Q7ZW11              387 VKH-SKNVYKAMGHYNV----AVPSDVSHYRFYFFFNKPLRILNILIILEGAMIFYQLYSLMCSE-KWHQTISLALILFS 460 zebrafish
1_pfamImport        336 VKH-NKNVYKAMGHYNV----AVPSDVSHFRFYFFFNKPLRILNILIILEGAVIFYQLYSLMSSE-KWHQIISLALILFS 409
XP_005317795        385 VKH-SKNVYKAVGHYNV----AIPSDVSHFRFHFFFSKPLRILNILLLLEGAVIVYQLYSLMSSE-KWHQTISLALILFS 458
OCA45307            378 VKH-NKNVYKAVGHYNV----AIPSDVSHFRFHFFFSNPLRVLNILTTLEGVLIFYQLYSLLSSE-KWHHTISLALILFS 451
Q6DF19              378 VKH-NKNVYKAVGHYNV----AIPSDVSHFRFHFFFSNPLRVLNILTTLEGVLIFYQLYSLLSSE-KWHHTISLALILFS 451 tropical...
Q5U2V9              456 NYYVLFKLLRDRIVLGRAYS 475 Norway rat
EKC27988            415 NYYTLFKLLRDRIILAKAYK 434
EFO84726            442 NYLLFAKLFKDKIILGRIYE 461
XP_001959491        401 SMGAFFKLVRDYLITKDLYK 420
WGS:AAQB:GK10634-PA 402 SMGAFFKLVRDYLITKHLYK 421
EDO41973            453 NYVILYRILRDRWALQGVLA 472
NP_955926           449 NYYVLFKLLRDRLVLGKAYS 468
XP_006639253        451 NYYVLFKLLRDRIVLGKAYS 470
Q7ZW11              461 NYYAFFKLLRDRIVLGKAYS 480 zebrafish
1_pfamImport        410 NYYAFFKLLRDRLVLGKAYA 429
XP_005317795        459 NYYAFFKLLRDRLVLGKAYS 478
OCA45307            452 NYYAFFKLLRDRIVLGKAYS 471
Q6DF19              452 NYYAFFKLLRDRIVLGKAYF 471 tropical clawed frog
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