5VBL


Conserved Protein Domain Family
7tmA_Apelin_R

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cd15190: 7tmA_Apelin_R 
Click on image for an interactive view with Cn3D
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.
Statistics
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PSSM-Id: 341340
Aligned: 8 rows
Threshold Bit Score: 450.753
Created: 11-Dec-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Structure:5VBL: Apelin receptor binds agonist peptide; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #####                                                                          
5VBL_B        37 CEYTDWKssgALIPAIYMLVFLLGTTGNGLVLWTVFRSSRekr-------------------------rsADIFIASLAV 91 
P79960        26 CDETDWDfsySLLPVFYMIVFVLGLSGNGVVIFTVWKSKPkr--------------------------rsADTYIGNLAL 79  African clawed ...
Q7SZP9        23 CDYSEWEpsySLIPVLYMLIFILGLSGNGVVIFTVWRAKSkr--------------------------raADVYIGNLAL 76  zebrafish
EMP27909      18 CEYEEWSpslVLLPTIYLLVFLLGTTGNGLVLWTIFRGGQekr-------------------------rsADTFIANLAM 72  green seaturtle
XP_001333516  16 CDYTEWSptwVLIPSVYLLVFVVGSLGNGLVLWVYLDRQArgrgrigsgskssqtpdsppcpsptstrtvTESLIISLAL 95  zebrafish
XP_005999317  21 CPFDEWEpsfALIPIIYFLIFILGLSGNGMVIWMVFHMKEkr--------------------------rsADTFIANLAL 74  coelacanth
XP_007900085  22 CDYSDWKhssAVVPVLYMLVFVFGLSGNGVVICTVWRSRTkr--------------------------rsADIYIGNLAL 75  elephant shark
P35414        19 CEYTDWKssgALIPAIYMLVFLLGTTGNGLVLWTVFRSSRekr-------------------------rsADIFIASLAV 73  human
Feature 1                   #  ## # #                #                                           
5VBL_B        92 ADLTFVVTLPLWATYTYRdYDWPFGtfFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIVrp-vaNARLRl-rVSGAVATA 169
P79960        80 ADLAFVVTLPLWATYTALgFHWPFGsaLCKLSSYLVLLNMFASVFCLTCLSFDRYLAIVhs-lsSAKLRs-rSSIIVSLA 157 African clawed ...
Q7SZP9        77 ADLTFVITLPLWAVYTALgYHWPFGvaLCKISSYVVLVNMYASVFCLTCLSFDRYLAIVhs-lsSGRLRs-rATMLASLG 154 zebrafish
EMP27909      73 ADLTFVVTLPLWAAYAWLgYHWPFGsfTCKLSSYLIFVNMHASVFCLMGLSIDRYLAIVrp-maNAKLRw-rASGLVATI 150 green seaturtle
XP_001333516  96 ADLAFVMTLPLWAAYTALgYHWPFGqvLCQTSSYIVALNMYASVFSLTGLSVERYCVITrqrgnGSKQRtssTRARWIVG 175 zebrafish
XP_005999317  75 ADLTFVVSLPLWAVYTAQrYHWVFGtfLCKLSSYLIYINMYASVFCLTCLSFDRYLAIVrs-maRSHLRs-kTSSFMAII 152 coelacanth
XP_007900085  76 ADLAFVVTLPLWAVYAALeYHWAFGslLCKVSSYLVMVNMYASIFCLTCLSFDRYLAIVys-lsSTKLRs-rESMILSLG 153 elephant shark
P35414        74 ADLTFVVTLPLWATYTYRdYDWPFGtfFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVrp-vaNARLRl-rVSGAVATA 151 human
Feature 1                        #          #####           # #                    #             
5VBL_B       170 VLWVLAALLAMPVMVLRtt------gdLENTNk------vQCYMDYSmvatv--------ssewaWEVGLGVSSTTVGFV 229
P79960       158 VIWLFSGLLALPSLILRdt-------rVEGNNt-------ICDLDFSgvssk--------enenfWIGGLSILTTVPGFL 215 African clawed ...
Q7SZP9       155 AIWFLSCLLAVPTLLFRtt------vdDTGSNr------tTCAMDFSlvtlnq-------dheslWIAGLSLSSSALGFL 215 zebrafish
EMP27909     151 ALWALAAILALPAMILRqa------avLLGETk------vTCYMDYSglvan--------gtegaWEVGLGLSSTMLGFV 210 green seaturtle
XP_001333516 176 IVWLAAGVLALPALLLRtvrepdlesgDDGDWqagqssscLCDMDYSslissdldpaeaeqaelmWSAALGLKSTLLGFL 255 zebrafish
XP_005999317 153 VVWVLAAILALPALVFRst------sgHEAPN--------SCFMDFSfaveee-------eeeifWTAGLGISYTVLGFV 211 coelacanth
XP_007900085 154 MIWLLAGILALPALILRq--------tQEKYNr------tICDMDFSvvgdt--------dvehyWIAGLSLSATAMGFL 211 elephant shark
P35414       152 VLWVLAALLAMPVMVLRtt------gdLENTTk------vQCYMDYSmvatv--------ssewaWEVGLGVSSTTVGFV 211 human
Feature 1                                                                                        
5VBL_B       230 VPFTIMLTCYFFIAQTIAMKkytctvcgyiynpedgdpdngvnpgtdfkdipddwvcplcgvgkdqfeevEERRRLLSII 309
P79960       216 LPLLLMTIFYCFIGGKVTMHfqnl------------------------------------------kkeeQKKKRLLKII 253 African clawed ...
Q7SZP9       216 LPFLAMTVCYCFIGCTVTRHfshl------------------------------------------rkedQKKRRLLKII 253 zebrafish
EMP27909     211 VPFVVMLTCYFFIARTIADHfrker-----------------------------------------seelRKRKRLLSII 249 green seaturtle
XP_001333516 256 LPLVVLLVCYGWLGRLLSRHfslgl-----------------------------------------rpdqKRQRRLLRII 294 zebrafish
XP_005999317 212 LPFCIMTTCYFAIGRTVAQHfqkh-------------------------------------------kedLRKRRLLTII 248 coelacanth
XP_007900085 212 LPFLLMSIFYCSIANTVTRHfhni------------------------------------------kkeeKKKRRLLKII 249 elephant shark
P35414       212 VPFTIMLTCYFFIAQTIAGHfrker-----------------------------------------ieglRKRRRLLSII 250 human
Feature 1                     #   #  #                     #   #   #                     
5VBL_B       310 VVLVVTFALCKMPYHLVKTLYmlgsl--lhwpCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDprFRQAC 379
P79960       254 ITLVVVFAICWLPFHILKTIHfldlmgflelsCSTQNIIVSLHPYATCLAYVNSCLNPFLYAFFDlrFRSQC 325 African clawed frog
Q7SZP9       254 TTLVVVFAFCWTPFHVLKSMDalsyldlapnsCGFLHFLLLAHPYATCLAYVNSCLNPFLYAFFDlrFRSQC 325 zebrafish
EMP27909     250 IVLVATFALCWLPYHLVKTIYvlmdlevmpwsCGFHAFLSNLHPYCTCVAYINSCLNPFLYAFFDprFRQAC 321 green seaturtle
XP_001333516 295 ITLVLAFFLCWLPFHTNKTLSamvelgilpfsCRFDQWLVAAHPYSICLGYVNSCLNPLLYACCDpaFRKRC 366 zebrafish
XP_005999317 249 ATLVATFAACWLPFHLVSTMYnlmyldvipfsCGLERFLMIVYPYATCLAYINSCVNPFLYAFFDlrFRAQC 320 coelacanth
XP_007900085 250 VTLVLVFGNCWLPFHILKTIDalfwleivpfsCSVDEFIYIAHPYATCLAYVNSCLNPFLYAFFDqrFRAQC 321 elephant shark
P35414       251 VVLVVTFALCWMPYHLVKTLYmlgsl--lhwpCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDprFRQAC 320 human

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