4AE4


Conserved Protein Domain Family
UBA2_UBAP1_like
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cd14316: UBA2_UBAP1_like 
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UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins
UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.
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Statistics
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PSSM-Id: 270501
Aligned: 23 rows
Threshold Bit Score: 47.1373
Created: 24-Jul-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:4AE4; Homo sapiens UBAP-1 in complex with ubiquitin through a solenoid of overlapping UBAs (SOUBA) domain, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #  ##             
4AE4_A        76 FLQLXSKFKEXGFELKDIKEVLLLHNNDQDNALEDLX 112 human
NP_001087614 443 FLQLMSKFKEMGFEQKDIKEVLLLHNNDQDKALEELM 479 African clawed frog
NP_956508    254 FLQLMSRFGEMGFERDTIKEVLLVHNNDQDKALEDLM 290 zebrafish
XP_002592261 484 YLSLLLKFEEMGFPQDKIKEALIVCSNDEHKALDMLM 520 Florida lancelet
AFJ51895     458 ILQLMSKFQEMGFKLKDIKEALLLHNNDQDNALEDLM 494 eastern diamondback rattlesnake
F5GYI3       341 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 377 human
XP_002121417 459 YLQLQRKFHDMGFTDDKIKQALLLHNGNETNALEALV 495 Ciona intestinalis
CAG05534     334 FLHLLNQFNEMGFQQNAIKEVLLVHENHRERALEELM 370 spotted green pufferfish
XP_799201    496 FLKLWQRFEELGFQAEDIKRELIVHGNDEEKVLDTLT 532 purple urchin
XP_004308022 194 FVNGFNHLHEMGFPSDSVADALLMYDNDKEKALAYLI 230 Fragaria vesca subsp. vesca

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