5GUP


Conserved Protein Domain Family
NDUF_B8
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pfam05821: NDUF_B8 
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NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits.
Links
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Statistics
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PSSM-Id: 428637
Aligned: 6 rows
Threshold Bit Score: 258.261
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5GUP_c         28 TASHVT------KDMFPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGM--GYGDYPKLPDRSQQERDPWYDWDHPDLRL 99  
EOA97283        7 AASGLT------SEMLPGPYPRTPEERAAAAKKYNMRVEDYQPYPDDGL--GYGDYPMLPKRSAHERDPWYQWDQPDIRH 78  
NP_001138314   28 TASHVT------KDMFPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGM--GYGDYPKLPDRSQQERDPWYDWDHPDLRL 99  
Q6P5L5         30 AASGSS------KDSLPGPYPKTAEEKAAAAKKYNMRPEDYQPYPDDGW--GSGDYPMLPSRSQHERDPYYQWDHPDLRR 101  zebrafish
Q9XWJ6         24 MRGPLTfdgwypRDHKPSAPPTNEEERRAAAVKYGLRPEDYQSMDKDDVikFAGDYPDLGVITYDHKDPYEAWTDRQNRR 103  Caenorhabditi...
PDM62081       23 LRGPLTfdgwypRDHKPGQYPENEEERRRAAIKYGLRPEDYKPMDKDDIvrYAGDYPDLGVVTYDHKDPYESWTDRNHRR 102 

5GUP_c        100 NWGEPIHWDLDMYIRNRVD----TSPTPVSWNTMCKHLFGFVAFMLFMFWVGEIYPS----YQPVGPKQYPYNDLYLERG 171 
EOA97283       79 NWGEPMHWDFDMYIRNRFD----TSPTQIPWHTMRKHFLVFLSTMLIMFGIGEFYPS----YRPVGPKQYPFNDLYLERG 150 
NP_001138314  100 NWGEPIHWDLDMYIRNRVD----TSPTPVSWNTMCKHLSGFVAFMLFMFWVGEIYPS----YQPVGPKQYPYNDLYLERG 171 
Q6P5L5        102 NWGEPMHYHFDMYIRNRVD----TSPTPLDWRTMRLWLFGFLGLTMFMFGMGEVLPS----YQPVAAKQYPYNNLYLERG 173  zebrafish
Q9XWJ6        104 NWGELVPIDMMRYRGDRLTftglEAEDYTTWNSIVMCLRVLVPMALLAWYFTNEHPNalrwKNPAMPKQYSYDFYRAYPF 183  Caenorhabditi...
PDM62081      103 NWGEMVGMDMMNYRGDRLTftglEAEDYTTWASIKMCLRVLVPMALLAYYFSREDPNafrwKNPAMPKQYPYDFARSFPF 182 

5GUP_c        172 GDPTKEPepVVHYEI 186 
EOA97283      151 GDPNKEApvVTHYEI 165 
NP_001138314  172 GDPTKEPepVVHYEI 186 
Q6P5L5        174 GDPEKEPepVKNYEI 188  zebrafish
Q9XWJ6        184 DDPRKYP--IVNYSF 196  Caenorhabditis elegans
PDM62081      183 DDPRKFP--IVNYSF 195
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