2ENO


Conserved Protein Domain Family
PDZ_SYNJ2BP-like

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cd06709: PDZ_SYNJ2BP-like 
PDZ domain of synaptojanin-2-binding protein (SYNJ2BP), and related domains
PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of SYNJ2BP, and related domains. SYNJ2BP (also known as mitochondrial outer membrane protein 25, OMP25) regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Binding partners of the SYNJ2BP PDZ domain include activin type II receptors (ActR-II), and SYNJ2. SYNJ2BP interacts with the PDZ binding motif of the Notch Delta-like ligand 1 (DLL1) and DLL4, promoting Delta-Notch signaling, and inhibiting sprouting angiogenesis. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This SYNJ2BP-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Statistics
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PSSM-Id: 467193
Aligned: 13 rows
Threshold Bit Score: 143.201
Created: 13-Jul-2007
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #######                #  #                             #   #  ##    
2ENO_A        19 EEINLTRGp-SGLGFNIVGGTDQQYVsnDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKnllHQDAVDLFRNAGy 97  human
NP_001085256  10 EEIALTRGp-SGLGFNIIGGTDQQYIahDSGIYVSSIKEKGAAAADGRLQEGDQILEVNGFKMEdllHNAAVDLFRNAGe 88  African clawed ...
P57105        12 EEINLTRGp-SGLGFNIVGGTDQQYVsnDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKnllHQDAVDLFRNAGy 90  human
NP_956211     12 VEFTLKRGp-AGLGFNIVGGVDQQYMmnDSGIYVAKIKENGAAALDGRLQEGDKILAINGRKLDnlsHGAAVELFRSAGe 90  zebrafish
ELT99315      10 LEIDLERGd-SGLGFNIKGGVDSPYIpdDPGVFIAKIRETGAAAQNGKLHEGDKIVEVNGQNVEnmkHQDVVNLFLASGs 88  Capitella teleta
XP_013405737   6 VEIELDRGk-TGLGFNIRGGSDIPYIqgDSGIFVTKIRDDGAAAADGRLQEGDKIIEINGSNVEsvtHNDAVNLFLNAGe 84  Lingula anatina
NP_001264717  13 EVIRLTRGp-SGLGFNIVGGTDQQVDsnDSSIYVSRIKKDGPAHLDGRLQEGDKILAINGRDLKnlrHMDAVELFKNAGy 91  chicken
XP_004226645  10 AVIKLERGg-SGLGFNIRGGVDQPHLpnDTGIFVTKIRENCAADIDGRLKEGDKLIEINGKSLIevkHSEAVDYFLTAGe 88  vase tunicate
XP_014349130  12 VEIQLKRGp-TGLGFNIVGGIDQLYIskDAAIIVTKIKPDGAAHTDGRLQEGDKILKINEHDLRnitHQQAVELFRNAGd 90  coelacanth
XP_007891455  48 EEIRLKRGk-RGLGFNIVGGTDHQYNynDSAIYVSKIKEDGPADADGRLKEGDQILAINGQVLCdmtHLEVVEVFRNSGd 126 elephant shark
XP_013067029  15 SEITLHRGe-TGLGFNIRGGTDIPHFkeDTGIFVTKLKEAGAAYRDGRLKEGDKILEVNGHKIQsvtHNEAVQIFITAGe 93  Biomphalaria gl...
XP_007896663   9 HTITLKRGg-TGFGFNILGGVDNPCYpgDNAIYVAKIREKESAAIDGRLKEGDKILQAGGVSLVniqHDKAAQVFKNIKn 87  elephant shark
XP_029637715  13 DEIVLYRDehVGLGFNIRGGIDMPLAw-DTGIFVARIKEKEAADIDGRLEEGDKILEVNGQSLEnlpHSEAVKIFLSAGn 91  Octopus sinensis
Feature 1               
2ENO_A        98 AVSLRVQ 104 human
NP_001085256  89 NVLLKVR 95  African clawed frog
P57105        91 AVSLRVQ 97  human
NP_956211     91 DVHLCIQ 97  zebrafish
ELT99315      89 NVKLKVW 95  Capitella teleta
XP_013405737  85 TVKLKVK 91  Lingula anatina
NP_001264717  92 DVSLKIQ 98  chicken
XP_004226645  89 HVTLKVW 95  vase tunicate
XP_014349130  91 DVTLTIL 97  coelacanth
XP_007891455 127 EVVLQVV 133 elephant shark
XP_013067029  94 TVHLKVQ 100 Biomphalaria glabrata
XP_007896663  88 DVLILQI 94  elephant shark
XP_029637715  92 VVKLKVQ 98  Octopus sinensis

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