Conserved Protein Domain Family
GT29_ST3GAL2
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cd23979: GT29_ST3GAL2 
beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467707
Aligned: 6 rows
Threshold Bit Score: 593.386
Created: 29-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q16842        70 CACRRCMGDAga--sDWFDSHFdgnispvwtrenmdlpPDVQRWWMMLQPQFkshntNEVLEKLFQivpgenpyrfrdph 147 human
XP_007904019  71 CGCERCVGDPgv--sKWFDEHFnpdilplwtkanmkldLDVHNWWLMLQPQFkpsdiKEVLSKLFQtvpgdnpyepwdrs 148 elephant shark
NP_001004012  94 CACSRCVGDPgv--sDWFDENYdpdispvwirdniqlpSDVYYWWVMLQPQFkphniQQVLQRLFQvipgrspygswdpa 171 zebrafish
NP_001084518  71 CLCRQCLRQPgf--sAWFDSHYdasvspvwtlenrelsPEVQHWWMMLQPQFrshntPEILSQLFQiipgqnpykqqdpl 148 African clawed ...
NP_001303812  69 CTCARCLGDLgv--sDWFDENYnmdvlpvwtkeninlpPDVYYWWLMLQPQFkpynlKNVLGKLFEiipgmnpynswdpq 146 coelacanth
NP_989811     67 CACRRCPEDAaaaaaAWFDSRYdggvspvwtkenmelpPDVQRWWMMLQPQFkshntQEVLSKLFQivpgenpyrwrdpr 146 chicken

Feature 1                ###                    ##                    #                          
Q16842       148 qCRRCAVVGNSGNlrgsgyGQDVDGHNFIMRMNqAPTVGfeqDVGsRTTHHFMYPESAKNLpanVSFVLVPFKvlDLLWI 227 human
XP_007904019 149 rCRRCAVVGNSGNlhgsqyGNQIDSHDFIMRLNqAPTVGfeaDVGrRTTHHFMYPESAKNLpanVSFVLVPFKilDLLWI 228 elephant shark
NP_001004012 172 rCLRCAVVGNSGNlrgagyGPVIDGHDFIMRMNlAPTVGyeeDAGsRTTHHFMYPESAKNLaanVSFVLVPFKtlDLLWI 251 zebrafish
NP_001084518 149 sCRHCAVVGNSGNlrgssyGKDIDGHEFIMRINqAPTVGfemDVGsRTTHHFMYPESAKNLpanVSFVLVPFKalDLLWI 228 African clawed ...
NP_001303812 147 sCRRCAVVGNSGNlhgsgyGKAIDMHDFIMRINqAPTVGfeaDVGsRTTHHFMYPESAKNLapnVSFVLVPFKtlDLLWI 226 coelacanth
NP_989811    147 hCRRCAVVGNSGNlrgsgyGHEIDGHDFITRMNqAPTVGfegDVGsRTTHHFMYPESAKNLpanVSFVLVPFKtlDLLWI 226 chicken

Feature 1                                                          ###                 ##       #
Q16842       228 ASALSTGQIRFTYaPVKSFLRVDKEKVQIYNPAFFKYIHDRWtehhgRYPSTGMLVLFFALHvCDEVNVYGFGadsrgNW 307 human
XP_007904019 229 TSALSTGQIRFTYaPVKQFLRVDKDKVQIYNPGFFKYVHDKWtehhgRYPSTGMLVLFFALHvCDEVDVYGFGtdnkgNW 308 elephant shark
NP_001004012 252 TSALSTGQIRFTYaPVKQFLRVDKDKVQIFNPAFFKYIHDRWtrhhgRYPSTGMLVLFFALHvCDEVNVFGFGadsrgNW 331 zebrafish
NP_001084518 229 TSALSTGQIRFTYaPVKAFLRVDKEKVQIYNPAFFKYIHDRWtehhgRYPSTGMLVLFFALHvCDEVNVFGFGadsrgNW 308 African clawed ...
NP_001303812 227 TSALSTGEIRFTYaPVKQFLRVDKDKVQIYNPAFFKYIHDKWtehhgRYPSTGMLVLFFALHvCDEVDVYGFGadsrgNW 306 coelacanth
NP_989811    227 ASALSTGQIRFTYaPVKPFLRVDKEKVQIYNPAFFKYIHDRWtehhgRYPSTGMLVLFFALHvCDEVNVFGFGadsrgNW 306 chicken

Feature 1        ##                #                      
Q16842       308 HHYWENNryagefrktgVHDADFEAHIIDMLakaSKIEVYR 348 human
XP_007904019 309 HHYWENYkyagefrktgVHDADYEAKIINLLaaaGKIKVFR 349 elephant shark
NP_001004012 332 HHYWEQNrysgefrktgVHDADYEAQIIDKLakaGKISVFP 372 zebrafish
NP_001084518 309 HHYWENNryagefrktgVHDADFEAQIIDTLakeGKIKVYR 349 African clawed frog
NP_001303812 307 HHYWENNryagefrktgVHDADFEAHIIDSLvqiGKIRVYR 347 coelacanth
NP_989811    307 HHYWENNryagefrktgVHDADFEAHIIDMLaktSRIEVYR 347 chicken

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